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- W2561176991 abstract "B162 The tumor microenvironment plays a major role in establishing and maintaining tumoral angiogenesis. Previously we demonstrated that Bcl-2 expressing prostatic tumors, are not only more tumorigenic but are more angiogenic. Increased rates of angiogenesis could be due to these cancer cells overexpressing and secreting more angiogenic factors, specifically Vascular Endothelial Growth Factor (VEGF). We now report that VEGF stimulation induces Bcl-2 expression, stabilizes mRNA Bcl-2, and protects these endothelial cells from apoptosis. Indeed the importance of Bcl-2 expression is evident by the fact that four distinct pathways (i.e., mTOR, PI3K, PKC, and ERK) contribute to Bcl-2 expression in endothelial cells. Microarray analysis of VEGF stimulated Bcl-2 expressing endothelial cells triggered a transcriptional program of genes involved in cellular metabolism, cell recognition and communication, transport, and signal transduction. Collectively, these data suggest that Bcl-2 expression in endothelial cells plays a major role in differentiation, proliferation and resistance to apoptosis. Furthermore, these data provide a possible explanation for the observed association between Bcl-2 expression and enhanced angiogenesis." @default.
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- W2561176991 date "2007-11-01" @default.
- W2561176991 modified "2023-09-24" @default.
- W2561176991 title "Diverse regulation of Bcl-2 in microvascular endothelial cells leads to altered pattern of gene expression" @default.
- W2561176991 hasPublicationYear "2007" @default.
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