FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561214354> ?p ?o ?g. }

• W2561214354 abstract "Abstract Background. Most cases of acquired severe aplastic anaemia (SAA) are not associated with any other disease and are therefore classified as idiopathic. Hepatitis-associated aplastic anaemia (HAA) has been well described as a separate entity amongst the acquired aplastic anaemias. Aim of this study was to describe the epidemiology of HAA and to analyze treatment results obtained in Europe in the last 15 years. Patients and methods. We evaluated 198 HAA out of 3684 AA patients reported to the SAAWP Registry between 1990 and 2005. Median age at diagnosis was 15 years (range 1–87) .132 were male and 66 female. Year, month and season of diagnosis were analyzed, as well as all variable related to the type and outcome of first line therapy. Results.Prevalence of HAA amongst all acquired AA registered in Europe from 1990 to 2005 was 5.4% (198/3684).The majority of patients were male (66%), and median age was 15 years. The virus causing the hepatitis was unknown in most cases (94.5%) while only 11 / 198 (5.5%) were related to Hepatitis B or A virus infection. No significant differences were found in the prevalence according to the year, month or season of diagnosis. No geographic clusters could be identified. Seventy three HAA patients were treated with immunosuppression (IS) and 125 underwent Stem cell Transplantation (SCT): these were compared with 1539 and 2045 non-HAA patients given IS or SCT. The median age was significantly younger in the HAA as compared to the non-HAA patients (15 versus 20, p<0.0001). The median interval between diagnosis and treatment in IS and SCT was 8 and 67 days respectively. Median follow-up for surviving or deceased patients was 1356 and 155 days respectively. The actuarial survival at 10 years after IS was 66% for HAA and 52% for non-HAA (p=0.4). HLA identical sibling SCT produced survival of 83% in HAA and 74% in non-HAA patients (p=0.1); when the donor was unrelated, survival was respectively 63% and 52% (p=0.5). After stratification for stem cell source, actuarial survival was 83% vs 72% (p=0.06) for bone marrow, and 68% vs 57% (p=0.5) for peripheral blood. Conclusions. The incidence of HAA in Europe is currently 5.4%, comparable with published data, and seems to be distributed homogeneously over the years, months and geographic areas. Results after IS or SCT in HAA patients are comparable to those obtained in idiopatic acquired non-HAA, treated in the same period in Europe. Therefore, HAA should be managed according to current guidelines for idiopathic aplastic anemia." @default.
• W2561214354 created "2017-01-06" @default.
• W2561214354 creator A5003369543 @default.
• W2561214354 creator A5038143009 @default.
• W2561214354 creator A5040887076 @default.
• W2561214354 creator A5049172299 @default.
• W2561214354 creator A5068736817 @default.
• W2561214354 creator A5070706427 @default.
• W2561214354 creator A5079480540 @default.
• W2561214354 creator A5090166012 @default.
• W2561214354 date "2007-11-16" @default.
• W2561214354 modified "2023-10-13" @default.
• W2561214354 title "Hepatitis - Associated Aplastic Anaemia: Epidemiology and Treatment Results Obtained in Europe. A Report of the EBMT Aplastic Anemia Working Party." @default.
• W2561214354 doi "https://doi.org/10.1182/blood.v110.11.483.483" @default.
• W2561214354 hasPublicationYear "2007" @default.
• W2561214354 type Work @default.
• W2561214354 sameAs 2561214354 @default.
• W2561214354 citedByCount "2" @default.
• W2561214354 crossrefType "journal-article" @default.
• W2561214354 hasAuthorship W2561214354A5003369543 @default.
• W2561214354 hasAuthorship W2561214354A5038143009 @default.
• W2561214354 hasAuthorship W2561214354A5040887076 @default.
• W2561214354 hasAuthorship W2561214354A5049172299 @default.
• W2561214354 hasAuthorship W2561214354A5068736817 @default.
• W2561214354 hasAuthorship W2561214354A5070706427 @default.
• W2561214354 hasAuthorship W2561214354A5079480540 @default.
• W2561214354 hasAuthorship W2561214354A5090166012 @default.
• W2561214354 hasBestOaLocation W25612143542 @default.
• W2561214354 hasConcept C107130276 @default.
• W2561214354 hasConcept C126322002 @default.
• W2561214354 hasConcept C187212893 @default.
• W2561214354 hasConcept C203014093 @default.
• W2561214354 hasConcept C2776029263 @default.
• W2561214354 hasConcept C2780007613 @default.
• W2561214354 hasConcept C2780252810 @default.
• W2561214354 hasConcept C2781440808 @default.
• W2561214354 hasConcept C2911091166 @default.
• W2561214354 hasConcept C71924100 @default.
• W2561214354 hasConcept C90924648 @default.
• W2561214354 hasConceptScore W2561214354C107130276 @default.
• W2561214354 hasConceptScore W2561214354C126322002 @default.
• W2561214354 hasConceptScore W2561214354C187212893 @default.
• W2561214354 hasConceptScore W2561214354C203014093 @default.
• W2561214354 hasConceptScore W2561214354C2776029263 @default.
• W2561214354 hasConceptScore W2561214354C2780007613 @default.
• W2561214354 hasConceptScore W2561214354C2780252810 @default.
• W2561214354 hasConceptScore W2561214354C2781440808 @default.
• W2561214354 hasConceptScore W2561214354C2911091166 @default.
• W2561214354 hasConceptScore W2561214354C71924100 @default.
• W2561214354 hasConceptScore W2561214354C90924648 @default.
• W2561214354 hasLocation W25612143541 @default.
• W2561214354 hasLocation W25612143542 @default.
• W2561214354 hasLocation W25612143543 @default.
• W2561214354 hasOpenAccess W2561214354 @default.
• W2561214354 hasPrimaryLocation W25612143541 @default.
• W2561214354 hasRelatedWork W2012132673 @default.
• W2561214354 hasRelatedWork W2228422756 @default.
• W2561214354 hasRelatedWork W2276069215 @default.
• W2561214354 hasRelatedWork W2314260375 @default.
• W2561214354 hasRelatedWork W2924378690 @default.
• W2561214354 hasRelatedWork W3029253348 @default.
• W2561214354 hasRelatedWork W4205589580 @default.
• W2561214354 hasRelatedWork W4281290036 @default.
• W2561214354 hasRelatedWork W4281294337 @default.
• W2561214354 hasRelatedWork W1967099730 @default.
• W2561214354 isParatext "false" @default.
• W2561214354 isRetracted "false" @default.
• W2561214354 magId "2561214354" @default.
• W2561214354 workType "article" @default.