FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561222015> ?p ?o ?g. }

• W2561222015 endingPage "110" @default.
• W2561222015 startingPage "100" @default.
• W2561222015 abstract "Intelectin is a recently discovered lectin that plays vital roles in the innate immune response, iron metabolism and early embryogenesis. The structure, expression pattern and function of intelectin in mammals and amphibians have been well studied, while not well known in fish. In this study, we cloned a intelectin (MamINTL) gene from blunt snout bream (Megalobrama amblycephala), examined its expression patterns and explored its roles in innate immune response. The MamINTL cDNA encoded 312 amino acids, with a pro-protein of 34 kDa. Sequence analysis revealed the presence of a fibrinogen-related domain and eight conserved cysteine residues in the MamINTL. The MamINTL mRNA was detectable at various developmental stages, while it increased significantly post hatching. In healthy adult M. amblycephala, MamINTL was detected in various tissues with the highest expression in the liver. Upon challenge with Aeromonas hydrophila, significantly up-regulated expression of the MamINTL mRNA was observed in the liver, spleen, kidney, intestine and gill. In addition, increased level of MamINTL protein detected by Western Blotting was also observed in the liver, kidney and spleen, indicating the participation of MamINTL in the immune response. Immunohistochemistry analysis of the M. amblycephala liver sections showed significant changes in expression and location post infection. In addition, the recombinant MamINTL showed excellent binding and agglutination activity against GFP-expressed E. coli in a Ca2+-dependent manner. Generally, the present study provides clues for a better understanding of the characterization, expression patterns and functions of fish intelectins." @default.
• W2561222015 created "2017-01-06" @default.
• W2561222015 creator A5002649440 @default.
• W2561222015 creator A5031594133 @default.
• W2561222015 creator A5032168913 @default.
• W2561222015 creator A5037472620 @default.
• W2561222015 creator A5039575874 @default.
• W2561222015 creator A5054658193 @default.
• W2561222015 creator A5067352712 @default.
• W2561222015 creator A5084985281 @default.
• W2561222015 date "2017-02-01" @default.
• W2561222015 modified "2023-10-14" @default.
• W2561222015 title "Characterization and expression analysis of an intelectin gene from Megalobrama amblycephala with excellent bacterial binding and agglutination activity" @default.
• W2561222015 cites W1544148572 @default.
• W2561222015 cites W1567731029 @default.
• W2561222015 cites W174822805 @default.
• W2561222015 cites W1972024114 @default.
• W2561222015 cites W1974145296 @default.
• W2561222015 cites W1979759393 @default.
• W2561222015 cites W1990474961 @default.
• W2561222015 cites W1992916416 @default.
• W2561222015 cites W2011426190 @default.
• W2561222015 cites W2019577213 @default.
• W2561222015 cites W2026858016 @default.
• W2561222015 cites W2035594567 @default.
• W2561222015 cites W2045010724 @default.
• W2561222015 cites W2046286791 @default.
• W2561222015 cites W2051500708 @default.
• W2561222015 cites W2055225412 @default.
• W2561222015 cites W2060169504 @default.
• W2561222015 cites W2061321571 @default.
• W2561222015 cites W2062021156 @default.
• W2561222015 cites W2067240694 @default.
• W2561222015 cites W2076332622 @default.
• W2561222015 cites W2081429882 @default.
• W2561222015 cites W2088404644 @default.
• W2561222015 cites W2091128056 @default.
• W2561222015 cites W2102414082 @default.
• W2561222015 cites W2114216755 @default.
• W2561222015 cites W2128063537 @default.
• W2561222015 cites W2129503012 @default.
• W2561222015 cites W2130865959 @default.
• W2561222015 cites W2132632499 @default.
• W2561222015 cites W2133183716 @default.
• W2561222015 cites W2164424403 @default.
• W2561222015 cites W2202888892 @default.
• W2561222015 cites W2257088752 @default.
• W2561222015 cites W2415859941 @default.
• W2561222015 cites W2439568641 @default.
• W2561222015 cites W924441542 @default.
• W2561222015 doi "https://doi.org/10.1016/j.fsi.2016.12.023" @default.
• W2561222015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28017903" @default.
• W2561222015 hasPublicationYear "2017" @default.
• W2561222015 type Work @default.
• W2561222015 sameAs 2561222015 @default.
• W2561222015 citedByCount "18" @default.
• W2561222015 countsByYear W25612220152018 @default.
• W2561222015 countsByYear W25612220152019 @default.
• W2561222015 countsByYear W25612220152020 @default.
• W2561222015 countsByYear W25612220152021 @default.
• W2561222015 countsByYear W25612220152022 @default.
• W2561222015 countsByYear W25612220152023 @default.
• W2561222015 crossrefType "journal-article" @default.
• W2561222015 hasAuthorship W2561222015A5002649440 @default.
• W2561222015 hasAuthorship W2561222015A5031594133 @default.
• W2561222015 hasAuthorship W2561222015A5032168913 @default.
• W2561222015 hasAuthorship W2561222015A5037472620 @default.
• W2561222015 hasAuthorship W2561222015A5039575874 @default.
• W2561222015 hasAuthorship W2561222015A5054658193 @default.
• W2561222015 hasAuthorship W2561222015A5067352712 @default.
• W2561222015 hasAuthorship W2561222015A5084985281 @default.
• W2561222015 hasConcept C104317684 @default.
• W2561222015 hasConcept C136449434 @default.
• W2561222015 hasConcept C150194340 @default.
• W2561222015 hasConcept C153911025 @default.
• W2561222015 hasConcept C187882448 @default.
• W2561222015 hasConcept C203014093 @default.
• W2561222015 hasConcept C2778130612 @default.
• W2561222015 hasConcept C2779441561 @default.
• W2561222015 hasConcept C523546767 @default.
• W2561222015 hasConcept C54355233 @default.
• W2561222015 hasConcept C86803240 @default.
• W2561222015 hasConcept C8891405 @default.
• W2561222015 hasConceptScore W2561222015C104317684 @default.
• W2561222015 hasConceptScore W2561222015C136449434 @default.
• W2561222015 hasConceptScore W2561222015C150194340 @default.
• W2561222015 hasConceptScore W2561222015C153911025 @default.
• W2561222015 hasConceptScore W2561222015C187882448 @default.
• W2561222015 hasConceptScore W2561222015C203014093 @default.
• W2561222015 hasConceptScore W2561222015C2778130612 @default.
• W2561222015 hasConceptScore W2561222015C2779441561 @default.
• W2561222015 hasConceptScore W2561222015C523546767 @default.
• W2561222015 hasConceptScore W2561222015C54355233 @default.
• W2561222015 hasConceptScore W2561222015C86803240 @default.
• W2561222015 hasConceptScore W2561222015C8891405 @default.
• W2561222015 hasFunder F4320321001 @default.
• W2561222015 hasFunder F4320335787 @default.
• W2561222015 hasLocation W25612220151 @default.

• next