FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561236475> ?p ?o ?g. }

• W2561236475 endingPage "e0168256" @default.
• W2561236475 startingPage "e0168256" @default.
• W2561236475 abstract "Perineuronal nets (PNNs) are aggregates of extracellular matrix that form structures surrounding a subset of GABAergic interneurons. The staining intensity of PNNs appears to be related to plasticity. Environmental enrichment (EE) influences plasticity during adulthood: EE decreases the rewarding effects of drugs of abuse and diminishes both drug- and sucrose-seeking behavior. We determined the impact of EE on PNN intensity in the medial prefrontal cortex (mPFC) in rats trained to self-administer sucrose. We examined the number and intensity of PNNs within the prelimbic (PL), infralimbic (IL), and orbitofrontal (OF) regions of the mPFC of adult Long-Evans rats that were trained for sucrose self-administration followed by acute or chronic EE during abstinence and a cue-induced reinstatement test. Rats exposed to EE prior to a cue-induced reinstatement of sucrose seeking had an increase in PNN staining compared with rats in standard housing. Conversely, naïve rats given 1 day of EE had a decrease in PNN intensity in the PL, no change in the IL, and an increase in the OF. Our findings demonstrate that EE increases PNN intensity in the mPFC after sucrose training, suggesting that training enhances the ability of EE to increase PNN intensity. We further demonstrate an interaction between time of abstinence, duration of EE exposure, and cue-induced reinstatement. Our results suggest that increased PNN intensity after EE may alter the excitatory/inhibitory balance of mPFC neurons such that rats are less responsive to a sucrose cue." @default.
• W2561236475 created "2017-01-06" @default.
• W2561236475 creator A5012730912 @default.
• W2561236475 creator A5022429042 @default.
• W2561236475 creator A5076619182 @default.
• W2561236475 creator A5081464815 @default.
• W2561236475 date "2016-12-15" @default.
• W2561236475 modified "2023-10-18" @default.
• W2561236475 title "Impact of Environmental Enrichment on Perineuronal Nets in the Prefrontal Cortex following Early and Late Abstinence from Sucrose Self-Administration in Rats" @default.
• W2561236475 cites W1889428062 @default.
• W2561236475 cites W1922497758 @default.
• W2561236475 cites W1973076339 @default.
• W2561236475 cites W1973274270 @default.
• W2561236475 cites W1989897544 @default.
• W2561236475 cites W1995481508 @default.
• W2561236475 cites W1996987711 @default.
• W2561236475 cites W1999827951 @default.
• W2561236475 cites W2002867031 @default.
• W2561236475 cites W2011159172 @default.
• W2561236475 cites W2012806030 @default.
• W2561236475 cites W2018040130 @default.
• W2561236475 cites W2023333383 @default.
• W2561236475 cites W2025806474 @default.
• W2561236475 cites W2025931153 @default.
• W2561236475 cites W2036261875 @default.
• W2561236475 cites W2054505706 @default.
• W2561236475 cites W2055031882 @default.
• W2561236475 cites W2055149660 @default.
• W2561236475 cites W2059869176 @default.
• W2561236475 cites W2080602594 @default.
• W2561236475 cites W2082407289 @default.
• W2561236475 cites W2084965555 @default.
• W2561236475 cites W2087207100 @default.
• W2561236475 cites W2091187766 @default.
• W2561236475 cites W2092537153 @default.
• W2561236475 cites W2095086005 @default.
• W2561236475 cites W2095889446 @default.
• W2561236475 cites W2096192426 @default.
• W2561236475 cites W2099040370 @default.
• W2561236475 cites W2099221443 @default.
• W2561236475 cites W2155669081 @default.
• W2561236475 cites W2172274087 @default.
• W2561236475 cites W2214549810 @default.
• W2561236475 cites W2529600742 @default.
• W2561236475 cites W644612366 @default.
• W2561236475 doi "https://doi.org/10.1371/journal.pone.0168256" @default.
• W2561236475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5158028" @default.
• W2561236475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27977779" @default.
• W2561236475 hasPublicationYear "2016" @default.
• W2561236475 type Work @default.
• W2561236475 sameAs 2561236475 @default.
• W2561236475 citedByCount "45" @default.
• W2561236475 countsByYear W25612364752017 @default.
• W2561236475 countsByYear W25612364752018 @default.
• W2561236475 countsByYear W25612364752019 @default.
• W2561236475 countsByYear W25612364752020 @default.
• W2561236475 countsByYear W25612364752021 @default.
• W2561236475 countsByYear W25612364752022 @default.
• W2561236475 countsByYear W25612364752023 @default.
• W2561236475 crossrefType "journal-article" @default.
• W2561236475 hasAuthorship W2561236475A5012730912 @default.
• W2561236475 hasAuthorship W2561236475A5022429042 @default.
• W2561236475 hasAuthorship W2561236475A5076619182 @default.
• W2561236475 hasAuthorship W2561236475A5081464815 @default.
• W2561236475 hasBestOaLocation W25612364751 @default.
• W2561236475 hasConcept C118552586 @default.
• W2561236475 hasConcept C126322002 @default.
• W2561236475 hasConcept C129987498 @default.
• W2561236475 hasConcept C134018914 @default.
• W2561236475 hasConcept C15744967 @default.
• W2561236475 hasConcept C169760540 @default.
• W2561236475 hasConcept C169900460 @default.
• W2561236475 hasConcept C17077164 @default.
• W2561236475 hasConcept C185592680 @default.
• W2561236475 hasConcept C2776559556 @default.
• W2561236475 hasConcept C2778597767 @default.
• W2561236475 hasConcept C2780687700 @default.
• W2561236475 hasConcept C2781195155 @default.
• W2561236475 hasConcept C47611674 @default.
• W2561236475 hasConcept C53927964 @default.
• W2561236475 hasConcept C55493867 @default.
• W2561236475 hasConcept C71924100 @default.
• W2561236475 hasConceptScore W2561236475C118552586 @default.
• W2561236475 hasConceptScore W2561236475C126322002 @default.
• W2561236475 hasConceptScore W2561236475C129987498 @default.
• W2561236475 hasConceptScore W2561236475C134018914 @default.
• W2561236475 hasConceptScore W2561236475C15744967 @default.
• W2561236475 hasConceptScore W2561236475C169760540 @default.
• W2561236475 hasConceptScore W2561236475C169900460 @default.
• W2561236475 hasConceptScore W2561236475C17077164 @default.
• W2561236475 hasConceptScore W2561236475C185592680 @default.
• W2561236475 hasConceptScore W2561236475C2776559556 @default.
• W2561236475 hasConceptScore W2561236475C2778597767 @default.
• W2561236475 hasConceptScore W2561236475C2780687700 @default.
• W2561236475 hasConceptScore W2561236475C2781195155 @default.
• W2561236475 hasConceptScore W2561236475C47611674 @default.
• W2561236475 hasConceptScore W2561236475C53927964 @default.
• W2561236475 hasConceptScore W2561236475C55493867 @default.

• next