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• W2561241607 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Clinical data suggests that both type 1 and type 2 diabetes are risk factors for AD-related dementia and several clinical studies have demonstrated that AD patients show alterations in peripheral glucose regulation characterized by insulin resistance (hyperinsulinemia) or hypoinsulinemia. Whether animal models of AD exhibit a pre-diabetic phenotype without additional dietary or experimental manipulation is unclear however, with contradictory data available. Further, most studies have not examined the time course of potential pre-diabetic changes relative to AD pathogenesis and cognitive decline. Thus, in this study we tested the hypothesis that a pre-diabetic phenotype (peripheral metabolic dysregulation) exists in the APP/PS1 transgenic model of AD under normal conditions and precedes AD-related pathology. Specifically, we examined glucose tolerance in male APP/PS1 mice on a C57BL/6J congenic background at 2, 4–6 and 8–9 months of age by assessing fasting glucose levels, glucose tolerance, plasma insulin levels and insulin sensitivity as well as the development of pathological characteristics of AD and verified that our APP/PS1 mice develop cognitive impairment. Here we show that APP/PS1 mice, compared to wild-type controls, exhibit a significant impairment in glucose tolerance during an intraperitoneal glucose tolerance test (ipGTT) and a trend for increased fasting plasma insulin concentrations as early as 2 months of age, while extracellular Aβ1–42 deposition occurs later and cognitive decline exists at 8–9 months of age. Moreover, APP/PS1 mice did not respond as well to exogenous insulin as the wild-type controls during an intraperitoneal insulin tolerance test (ipITT). Taken together, these data reveal that male APP/PS1 mice on a C57BL/6J congenic background exhibit a pre-diabetic phenotype prior to the development of AD-like pathology and that this metabolic deficit persists when they exhibit neuropathology and cognitive decline. This raises the question of whether altered glucose regulation and insulin production/secretion could contribute to AD pathogenesis." @default.
• W2561241607 created "2017-01-06" @default.
• W2561241607 creator A5019924930 @default.
• W2561241607 creator A5028420051 @default.
• W2561241607 creator A5057469411 @default.
• W2561241607 creator A5067400912 @default.
• W2561241607 creator A5082476734 @default.
• W2561241607 creator A5091472977 @default.
• W2561241607 date "2017-02-01" @default.
• W2561241607 modified "2023-10-05" @default.
• W2561241607 title "Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline" @default.
• W2561241607 cites W152311838 @default.
• W2561241607 cites W1526704928 @default.
• W2561241607 cites W1543788907 @default.
• W2561241607 cites W1546369396 @default.
• W2561241607 cites W1554596985 @default.
• W2561241607 cites W1566528879 @default.
• W2561241607 cites W1575834956 @default.
• W2561241607 cites W1575865875 @default.
• W2561241607 cites W1589427638 @default.
• W2561241607 cites W1657419816 @default.
• W2561241607 cites W1811135155 @default.
• W2561241607 cites W1812507791 @default.
• W2561241607 cites W1841850981 @default.
• W2561241607 cites W1855414735 @default.
• W2561241607 cites W1895530546 @default.
• W2561241607 cites W1964697747 @default.
• W2561241607 cites W1971003242 @default.
• W2561241607 cites W1971210753 @default.
• W2561241607 cites W1972609075 @default.
• W2561241607 cites W1975141413 @default.
• W2561241607 cites W1978304543 @default.
• W2561241607 cites W1982732238 @default.
• W2561241607 cites W1982795519 @default.
• W2561241607 cites W1982825693 @default.
• W2561241607 cites W1985579937 @default.
• W2561241607 cites W1988870963 @default.
• W2561241607 cites W1992431456 @default.
• W2561241607 cites W1994083528 @default.
• W2561241607 cites W1994188674 @default.
• W2561241607 cites W1995144868 @default.
• W2561241607 cites W1998526261 @default.
• W2561241607 cites W2001330707 @default.
• W2561241607 cites W2003776455 @default.
• W2561241607 cites W2004739315 @default.
• W2561241607 cites W2006404588 @default.
• W2561241607 cites W2007735264 @default.
• W2561241607 cites W2008337884 @default.
• W2561241607 cites W2012529359 @default.
• W2561241607 cites W2013343090 @default.
• W2561241607 cites W2015786514 @default.
• W2561241607 cites W2021280501 @default.
• W2561241607 cites W2025811936 @default.
• W2561241607 cites W2028416698 @default.
• W2561241607 cites W2028457208 @default.
• W2561241607 cites W2029428782 @default.
• W2561241607 cites W2031155126 @default.
• W2561241607 cites W2038205848 @default.
• W2561241607 cites W2043522411 @default.
• W2561241607 cites W2044112693 @default.
• W2561241607 cites W2045153164 @default.
• W2561241607 cites W2045409916 @default.
• W2561241607 cites W2046209489 @default.
• W2561241607 cites W2051993731 @default.
• W2561241607 cites W2054236377 @default.
• W2561241607 cites W2057013554 @default.
• W2561241607 cites W2057164916 @default.
• W2561241607 cites W2057960819 @default.
• W2561241607 cites W2060170946 @default.
• W2561241607 cites W2061613314 @default.
• W2561241607 cites W2062989356 @default.
• W2561241607 cites W2063575967 @default.
• W2561241607 cites W2066000496 @default.
• W2561241607 cites W2067902437 @default.
• W2561241607 cites W2070929636 @default.
• W2561241607 cites W2076102832 @default.
• W2561241607 cites W2079938040 @default.
• W2561241607 cites W2082005347 @default.
• W2561241607 cites W2082212339 @default.
• W2561241607 cites W2083579642 @default.
• W2561241607 cites W2084762017 @default.
• W2561241607 cites W2085572937 @default.
• W2561241607 cites W2086794706 @default.
• W2561241607 cites W2087243986 @default.
• W2561241607 cites W2089189236 @default.
• W2561241607 cites W2089269477 @default.
• W2561241607 cites W2093104385 @default.
• W2561241607 cites W2097553343 @default.
• W2561241607 cites W2098463163 @default.
• W2561241607 cites W2099589415 @default.
• W2561241607 cites W2104287008 @default.
• W2561241607 cites W2112256576 @default.
• W2561241607 cites W2115439850 @default.
• W2561241607 cites W2117839560 @default.
• W2561241607 cites W2131116946 @default.
• W2561241607 cites W2135190643 @default.
• W2561241607 cites W2141918279 @default.
• W2561241607 cites W2142587255 @default.

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