Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561263341> ?p ?o ?g. }
- W2561263341 abstract "A leukemic stem cell (LSC)-targeting Auger electron-emitting radioimmunotherapeutic agent for acute myeloid leukemia (AML) comprising the monoclonal antibody CSL360 with high affinity for the LSC CD123+/CD131- immunophenotype modified with indium-111 and a nuclear localization sequence peptide (111In-NLS-CSL360) was constructed and evaluated. Methods: CD123 immunoreactivity of 111In-NLS-CSL360 was measured. Toxicity and anti-leukemic effectiveness of a three-dose regimen of 111In-NLS-CSL360 were assessed in a NOD/SCID mouse model of AML. Results: Immunoreactivity of 111In-NLS-CSL360 was preserved. 111In-NLS-CSL360 was found to be non-toxic. While leukemic engraftment in the bone marrow was paradoxically increased by 111In-NLS-CSL360, splenic engraftment in mice with low disease burden was significantly lower than in mice treated with a control radioimmunoconjugate. Conclusion: 111In-NLS-CSL360 remains a promising investigational therapeutic agent for targeting LSCs, but due to complications with the NOD/SCID mouse model, an alternative strain of mice is recommended for future studies.%%%%M.Sc.%%%%2017-06-14 00:00:00" @default.
- W2561263341 created "2017-01-06" @default.
- W2561263341 creator A5088757247 @default.
- W2561263341 date "2015-06-01" @default.
- W2561263341 modified "2023-09-24" @default.
- W2561263341 title "Leukemic Stem Cell-targeting Auger Electron Radioimmunotherapeutic Agent for Acute Myeloid Leukemia" @default.
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