FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561314875> ?p ?o ?g. }

• W2561314875 endingPage "26" @default.
• W2561314875 startingPage "17" @default.
• W2561314875 abstract "The purpose of this study was to develop the surface modification of docetaxel nanocrystals (DTX-NCs) with apo-Transferrin human (Tf) for improving the cellular uptake and cytotoxicity of DTX. DTX-NCs were prepared by a nanoprecipitation method, and the surface modified with Tf by an adsorption method (Tf-DTX-NCs). The morphology and particle size of DTX-NCs and Tf-DTX-NCs were characterized using a field emission scanning electron microscope and zetasizer. An in vitro drug release study was performed in phosphate-buffered saline containing 0.5% (w/v) Tween 80 for 24 hours. Cellular uptake was studied at 0.5, 1, and 2 hours. A cytotoxicity study was performed using the A549 (human lung cancer) cell line after 24-, 48-, and 72-hour treatments. The mean sizes were 295±97 and 398±102 nm for DTX-NCs and Tf-DTX-NCs, respectively. Tf-DTX-NCs and DTX-NCs exhibited rapid drug release, whereas DTX (pure) was slowly released. Tf-DTX-NCs showed higher cellular uptake than DTX-NCs in confocal microscopic and quantitative studies. Moreover, at DTX concentration of 100 µg/mL, Tf-DTX-NCs (82.6%±0.8%) showed higher cytotoxicity than DTX-NCs (77.4%±4.1%) and DTX (pure; 20.1%±4.6%) for 72-hour treatment. In conclusion, Tf-DTX-NCs significantly improved the cellular uptake and cytotoxicity of DTX in the A549 cell line." @default.
• W2561314875 created "2017-01-06" @default.
• W2561314875 creator A5057506766 @default.
• W2561314875 creator A5071734868 @default.
• W2561314875 date "2016-12-01" @default.
• W2561314875 modified "2023-10-16" @default.
• W2561314875 title "Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting" @default.
• W2561314875 cites W1783355274 @default.
• W2561314875 cites W1854873010 @default.
• W2561314875 cites W1972885668 @default.
• W2561314875 cites W1981505680 @default.
• W2561314875 cites W1985010122 @default.
• W2561314875 cites W1986714589 @default.
• W2561314875 cites W1994191910 @default.
• W2561314875 cites W2002387745 @default.
• W2561314875 cites W2003192668 @default.
• W2561314875 cites W2003536865 @default.
• W2561314875 cites W2005451446 @default.
• W2561314875 cites W2007154517 @default.
• W2561314875 cites W2007253305 @default.
• W2561314875 cites W2007579059 @default.
• W2561314875 cites W2008564265 @default.
• W2561314875 cites W2016051420 @default.
• W2561314875 cites W2016227717 @default.
• W2561314875 cites W2020747873 @default.
• W2561314875 cites W2024862077 @default.
• W2561314875 cites W2028536670 @default.
• W2561314875 cites W2030275485 @default.
• W2561314875 cites W2038036349 @default.
• W2561314875 cites W2064802984 @default.
• W2561314875 cites W2065770625 @default.
• W2561314875 cites W2068796502 @default.
• W2561314875 cites W2069124347 @default.
• W2561314875 cites W2070932895 @default.
• W2561314875 cites W2072997205 @default.
• W2561314875 cites W2078158817 @default.
• W2561314875 cites W2079250887 @default.
• W2561314875 cites W2083840015 @default.
• W2561314875 cites W2086637105 @default.
• W2561314875 cites W2088659772 @default.
• W2561314875 cites W2093302389 @default.
• W2561314875 cites W2118213449 @default.
• W2561314875 cites W2123168883 @default.
• W2561314875 cites W2128717540 @default.
• W2561314875 cites W2129980493 @default.
• W2561314875 cites W2136141736 @default.
• W2561314875 cites W2142474074 @default.
• W2561314875 cites W2145012502 @default.
• W2561314875 cites W2161810664 @default.
• W2561314875 cites W2163196876 @default.
• W2561314875 cites W2173044124 @default.
• W2561314875 cites W2184440358 @default.
• W2561314875 cites W2219326255 @default.
• W2561314875 cites W2272216542 @default.
• W2561314875 cites W2283717297 @default.
• W2561314875 cites W2293110263 @default.
• W2561314875 cites W2294609210 @default.
• W2561314875 cites W2299370463 @default.
• W2561314875 cites W2324631901 @default.
• W2561314875 cites W2411030952 @default.
• W2561314875 cites W2483875397 @default.
• W2561314875 cites W2515098111 @default.
• W2561314875 cites W602062805 @default.
• W2561314875 doi "https://doi.org/10.2147/dddt.s122984" @default.
• W2561314875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5179213" @default.
• W2561314875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28031702" @default.
• W2561314875 hasPublicationYear "2016" @default.
• W2561314875 type Work @default.
• W2561314875 sameAs 2561314875 @default.
• W2561314875 citedByCount "35" @default.
• W2561314875 countsByYear W25613148752017 @default.
• W2561314875 countsByYear W25613148752018 @default.
• W2561314875 countsByYear W25613148752019 @default.
• W2561314875 countsByYear W25613148752020 @default.
• W2561314875 countsByYear W25613148752021 @default.
• W2561314875 countsByYear W25613148752022 @default.
• W2561314875 countsByYear W25613148752023 @default.
• W2561314875 crossrefType "journal-article" @default.
• W2561314875 hasAuthorship W2561314875A5057506766 @default.
• W2561314875 hasAuthorship W2561314875A5071734868 @default.
• W2561314875 hasBestOaLocation W25613148751 @default.
• W2561314875 hasConcept C109316439 @default.
• W2561314875 hasConcept C121608353 @default.
• W2561314875 hasConcept C12554922 @default.
• W2561314875 hasConcept C13965031 @default.
• W2561314875 hasConcept C153911025 @default.
• W2561314875 hasConcept C178790620 @default.
• W2561314875 hasConcept C185592680 @default.
• W2561314875 hasConcept C202751555 @default.
• W2561314875 hasConcept C22814914 @default.
• W2561314875 hasConcept C2777230088 @default.
• W2561314875 hasConcept C2781190966 @default.
• W2561314875 hasConcept C54355233 @default.
• W2561314875 hasConcept C55493867 @default.
• W2561314875 hasConcept C81729549 @default.
• W2561314875 hasConcept C81885089 @default.
• W2561314875 hasConcept C86803240 @default.
• W2561314875 hasConcept C98274493 @default.

• next