Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561342645> ?p ?o ?g. }
- W2561342645 endingPage "228" @default.
- W2561342645 startingPage "215" @default.
- W2561342645 abstract "Myocardial ischemia is one of the main causes of cardiac remodeling and heart failure. As a highly evolutionarily conserved pathway, the signal transducer and activator of transcription 3 (STAT3) signaling controls intercellular communication, signaling transduction and gene transcription. Interestingly, STAT3 signaling has been demonstrated to take part in myocardial ischemia. Furthermore, activation of STAT3 signaling contributes to the protective efficacy of various interventions, including pharmacological and non-pharmacological treatment of myocardial ischemic injury. Areas covered: We first introduce the protective mechanisms of STAT3. We then discuss STAT3 signaling in various cells and the roles of STAT3 in myocardial processes during myocardial ischemia. Finally, the roles of STAT3 in myocardial ischemia and the upstream regulators of STAT3 activation are summarized. Expert opinion: In various animal experiments, STAT3 has been demonstrated to take part in myocardial responses to myocardial ischemic injury and to be activated during various modes of protection against myocardial ischemia and ischemia/reperfusion (I/R) injury. However, further clinical evidence on the role of STAT3 in such protection is needed. Treatments targeting STAT3 as a means of reducing myocardial ischemic injury need to be tested in a clinical setting. Furthermore, biotechnology can be used to develop effective drugs for this purpose." @default.
- W2561342645 created "2017-01-06" @default.
- W2561342645 creator A5009043320 @default.
- W2561342645 creator A5011830721 @default.
- W2561342645 creator A5018129328 @default.
- W2561342645 creator A5042525008 @default.
- W2561342645 creator A5049692788 @default.
- W2561342645 creator A5051325364 @default.
- W2561342645 creator A5052456561 @default.
- W2561342645 creator A5052780403 @default.
- W2561342645 creator A5058595812 @default.
- W2561342645 creator A5064038450 @default.
- W2561342645 creator A5071803801 @default.
- W2561342645 date "2016-12-27" @default.
- W2561342645 modified "2023-10-18" @default.
- W2561342645 title "Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site" @default.
- W2561342645 cites W1492237391 @default.
- W2561342645 cites W1505447562 @default.
- W2561342645 cites W1528084970 @default.
- W2561342645 cites W1545911557 @default.
- W2561342645 cites W1567849762 @default.
- W2561342645 cites W1630472384 @default.
- W2561342645 cites W1689013343 @default.
- W2561342645 cites W1713084803 @default.
- W2561342645 cites W1913262543 @default.
- W2561342645 cites W1931137354 @default.
- W2561342645 cites W1967366037 @default.
- W2561342645 cites W1967581712 @default.
- W2561342645 cites W1967612089 @default.
- W2561342645 cites W1968421845 @default.
- W2561342645 cites W1971308765 @default.
- W2561342645 cites W1972503373 @default.
- W2561342645 cites W1974124559 @default.
- W2561342645 cites W1978966324 @default.
- W2561342645 cites W1980602136 @default.
- W2561342645 cites W1981214582 @default.
- W2561342645 cites W1981558989 @default.
- W2561342645 cites W1981694995 @default.
- W2561342645 cites W1982605537 @default.
- W2561342645 cites W1983002549 @default.
- W2561342645 cites W1983807092 @default.
- W2561342645 cites W1991473626 @default.
- W2561342645 cites W1992332114 @default.
- W2561342645 cites W1992775792 @default.
- W2561342645 cites W1992911714 @default.
- W2561342645 cites W1993569315 @default.
- W2561342645 cites W1994823455 @default.
- W2561342645 cites W1995575524 @default.
- W2561342645 cites W1996452878 @default.
- W2561342645 cites W1997282845 @default.
- W2561342645 cites W2001063848 @default.
- W2561342645 cites W2002140031 @default.
- W2561342645 cites W2002424665 @default.
- W2561342645 cites W2003481724 @default.
- W2561342645 cites W2006312889 @default.
- W2561342645 cites W2006732787 @default.
- W2561342645 cites W2007554420 @default.
- W2561342645 cites W2008915773 @default.
- W2561342645 cites W2009177754 @default.
- W2561342645 cites W2009316212 @default.
- W2561342645 cites W2009435405 @default.
- W2561342645 cites W2010161773 @default.
- W2561342645 cites W2012517632 @default.
- W2561342645 cites W2013085806 @default.
- W2561342645 cites W2013800949 @default.
- W2561342645 cites W2016215203 @default.
- W2561342645 cites W2016369333 @default.
- W2561342645 cites W2016997557 @default.
- W2561342645 cites W2018823286 @default.
- W2561342645 cites W2021939481 @default.
- W2561342645 cites W2022473516 @default.
- W2561342645 cites W2022846817 @default.
- W2561342645 cites W2024185649 @default.
- W2561342645 cites W2026977120 @default.
- W2561342645 cites W2027075170 @default.
- W2561342645 cites W2027589607 @default.
- W2561342645 cites W2028934633 @default.
- W2561342645 cites W2029077404 @default.
- W2561342645 cites W2029294373 @default.
- W2561342645 cites W2031132231 @default.
- W2561342645 cites W2036994417 @default.
- W2561342645 cites W2037011709 @default.
- W2561342645 cites W2041231665 @default.
- W2561342645 cites W2042011422 @default.
- W2561342645 cites W2042503285 @default.
- W2561342645 cites W2042777460 @default.
- W2561342645 cites W2043291701 @default.
- W2561342645 cites W2043347179 @default.
- W2561342645 cites W2043355876 @default.
- W2561342645 cites W2043884012 @default.
- W2561342645 cites W2044227662 @default.
- W2561342645 cites W2044951529 @default.
- W2561342645 cites W2046566019 @default.
- W2561342645 cites W2046984116 @default.
- W2561342645 cites W2047289186 @default.
- W2561342645 cites W2048088159 @default.
- W2561342645 cites W2053595149 @default.
- W2561342645 cites W2056892039 @default.