Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561377413> ?p ?o ?g. }
- W2561377413 endingPage "603" @default.
- W2561377413 startingPage "589" @default.
- W2561377413 abstract "Abstract Chromatin boundary elements subdivide chromosomes in multicellular organisms into physically independent domains. In addition to this architectural function, these elements also play a critical role in gene regulation. Here we investigated the evolution of a Drosophila Bithorax complex boundary element called Fab-7, which is required for the proper parasegment specific expression of the homeotic Abd-B gene. Using a “gene” replacement strategy, we show that Fab-7 boundaries from two closely related species, D. erecta and D. yakuba, and a more distant species, D. pseudoobscura, are able to substitute for the melanogaster boundary. Consistent with this functional conservation, the two known Fab-7 boundary factors, Elba and LBC, have recognition sequences in the boundaries from all species. However, the strategies used for maintaining binding and function in the face of sequence divergence is different. The first is conventional, and depends upon conservation of the 8 bp Elba recognition sequence. The second is unconventional, and takes advantage of the unusually large and flexible sequence recognition properties of the LBC boundary factor, and the deployment of multiple LBC recognition elements in each boundary. In the former case, binding is lost when the recognition sequence is altered. In the latter case, sequence divergence is accompanied by changes in the number, relative affinity, and location of the LBC recognition elements." @default.
- W2561377413 created "2017-01-06" @default.
- W2561377413 creator A5005729563 @default.
- W2561377413 creator A5013501799 @default.
- W2561377413 creator A5016352223 @default.
- W2561377413 creator A5020157703 @default.
- W2561377413 creator A5049841678 @default.
- W2561377413 creator A5072866654 @default.
- W2561377413 creator A5083361489 @default.
- W2561377413 creator A5084013728 @default.
- W2561377413 date "2017-02-01" @default.
- W2561377413 modified "2023-09-27" @default.
- W2561377413 title "Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex" @default.
- W2561377413 cites W1043327939 @default.
- W2561377413 cites W1480204269 @default.
- W2561377413 cites W151923079 @default.
- W2561377413 cites W1612828742 @default.
- W2561377413 cites W1891332773 @default.
- W2561377413 cites W1970321798 @default.
- W2561377413 cites W1973062929 @default.
- W2561377413 cites W1977597159 @default.
- W2561377413 cites W1980408851 @default.
- W2561377413 cites W1982700926 @default.
- W2561377413 cites W1986232151 @default.
- W2561377413 cites W1988523481 @default.
- W2561377413 cites W1989373989 @default.
- W2561377413 cites W1995576030 @default.
- W2561377413 cites W1998210025 @default.
- W2561377413 cites W2000626262 @default.
- W2561377413 cites W2002964220 @default.
- W2561377413 cites W2006354791 @default.
- W2561377413 cites W2006788765 @default.
- W2561377413 cites W2009151187 @default.
- W2561377413 cites W2009529118 @default.
- W2561377413 cites W2012674191 @default.
- W2561377413 cites W2028325858 @default.
- W2561377413 cites W2029722028 @default.
- W2561377413 cites W2033141201 @default.
- W2561377413 cites W2033780586 @default.
- W2561377413 cites W2035297312 @default.
- W2561377413 cites W2035726665 @default.
- W2561377413 cites W2041102576 @default.
- W2561377413 cites W2044726214 @default.
- W2561377413 cites W2049839274 @default.
- W2561377413 cites W2050161311 @default.
- W2561377413 cites W2050296956 @default.
- W2561377413 cites W2052112605 @default.
- W2561377413 cites W2053759508 @default.
- W2561377413 cites W2056482755 @default.
- W2561377413 cites W2058834628 @default.
- W2561377413 cites W2059449682 @default.
- W2561377413 cites W2061020451 @default.
- W2561377413 cites W2064251573 @default.
- W2561377413 cites W2065671500 @default.
- W2561377413 cites W2070168243 @default.
- W2561377413 cites W2073747699 @default.
- W2561377413 cites W2083104168 @default.
- W2561377413 cites W2088016816 @default.
- W2561377413 cites W2107895168 @default.
- W2561377413 cites W2110884134 @default.
- W2561377413 cites W2116038761 @default.
- W2561377413 cites W2133983335 @default.
- W2561377413 cites W2136583745 @default.
- W2561377413 cites W2140538490 @default.
- W2561377413 cites W2145380525 @default.
- W2561377413 cites W2146743044 @default.
- W2561377413 cites W2147372710 @default.
- W2561377413 cites W2149611486 @default.
- W2561377413 cites W2155940790 @default.
- W2561377413 cites W2157576490 @default.
- W2561377413 cites W2159192458 @default.
- W2561377413 cites W2166711485 @default.
- W2561377413 cites W2171172006 @default.
- W2561377413 cites W2275372717 @default.
- W2561377413 cites W2279365238 @default.
- W2561377413 cites W2310966659 @default.
- W2561377413 cites W2496459787 @default.
- W2561377413 doi "https://doi.org/10.1534/genetics.116.195586" @default.
- W2561377413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5289839" @default.
- W2561377413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28007886" @default.
- W2561377413 hasPublicationYear "2017" @default.
- W2561377413 type Work @default.
- W2561377413 sameAs 2561377413 @default.
- W2561377413 citedByCount "14" @default.
- W2561377413 countsByYear W25613774132017 @default.
- W2561377413 countsByYear W25613774132018 @default.
- W2561377413 countsByYear W25613774132019 @default.
- W2561377413 countsByYear W25613774132020 @default.
- W2561377413 countsByYear W25613774132021 @default.
- W2561377413 countsByYear W25613774132022 @default.
- W2561377413 countsByYear W25613774132023 @default.
- W2561377413 crossrefType "journal-article" @default.
- W2561377413 hasAuthorship W2561377413A5005729563 @default.
- W2561377413 hasAuthorship W2561377413A5013501799 @default.
- W2561377413 hasAuthorship W2561377413A5016352223 @default.
- W2561377413 hasAuthorship W2561377413A5020157703 @default.
- W2561377413 hasAuthorship W2561377413A5049841678 @default.
- W2561377413 hasAuthorship W2561377413A5072866654 @default.