Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561409078> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2561409078 abstract "Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killing by boosting complement. In the present study, we showed the mechanism behind the classical complement activation by the TFPI-1 C-terminal GGL27 peptide. Protein-peptide interaction studies revealed that GGL27 peptide binds to IgM, IgG and to all IgG subunits. Importantly, IgG-GGL27 peptide interactions are facilitated through the Fc binding region. Furthermore, we showed that complement-mediated killing against E. coli by TFPI-1-derived peptides is evolutionarily conserved only in mammals except rodents, but not in reptiles, birds and fish due to absence of IgG. This complement-mediated killing is diminished when IgG is deactivated. Moreover, boosting of complement on bacterial surface by GGL27 shows an augmentation of phagocytosis activity. A previous study showed that GGL27 has an anti-coagulant activity in human plasma by blocking the intrinsic pathway, here we display the presence of anti-coagulant activity in mammalian and reptile peptides, while bird and fish peptides lack anti-coagulant activity. Finally, in vivo we showed that mouse TFPI-2-derived peptide (VKG24) is protective against bacterial infection. These findings conclude that vertebrate TFPI-derived peptides may exert a potential therapeutic approach against bacterial infections. (Less)" @default.
- W2561409078 created "2017-01-06" @default.
- W2561409078 creator A5008394696 @default.
- W2561409078 date "2016-01-01" @default.
- W2561409078 modified "2023-09-26" @default.
- W2561409078 title "C-terminal TFPI-1-derived peptides: their evolutionary host defense functions" @default.
- W2561409078 hasPublicationYear "2016" @default.
- W2561409078 type Work @default.
- W2561409078 sameAs 2561409078 @default.
- W2561409078 citedByCount "0" @default.
- W2561409078 crossrefType "journal-article" @default.
- W2561409078 hasAuthorship W2561409078A5008394696 @default.
- W2561409078 hasConcept C104317684 @default.
- W2561409078 hasConcept C111684460 @default.
- W2561409078 hasConcept C136449434 @default.
- W2561409078 hasConcept C14356644 @default.
- W2561409078 hasConcept C160448771 @default.
- W2561409078 hasConcept C167625842 @default.
- W2561409078 hasConcept C171279029 @default.
- W2561409078 hasConcept C203014093 @default.
- W2561409078 hasConcept C2779281246 @default.
- W2561409078 hasConcept C540938839 @default.
- W2561409078 hasConcept C55493867 @default.
- W2561409078 hasConcept C86803240 @default.
- W2561409078 hasConcept C8891405 @default.
- W2561409078 hasConcept C89423630 @default.
- W2561409078 hasConcept C95444343 @default.
- W2561409078 hasConceptScore W2561409078C104317684 @default.
- W2561409078 hasConceptScore W2561409078C111684460 @default.
- W2561409078 hasConceptScore W2561409078C136449434 @default.
- W2561409078 hasConceptScore W2561409078C14356644 @default.
- W2561409078 hasConceptScore W2561409078C160448771 @default.
- W2561409078 hasConceptScore W2561409078C167625842 @default.
- W2561409078 hasConceptScore W2561409078C171279029 @default.
- W2561409078 hasConceptScore W2561409078C203014093 @default.
- W2561409078 hasConceptScore W2561409078C2779281246 @default.
- W2561409078 hasConceptScore W2561409078C540938839 @default.
- W2561409078 hasConceptScore W2561409078C55493867 @default.
- W2561409078 hasConceptScore W2561409078C86803240 @default.
- W2561409078 hasConceptScore W2561409078C8891405 @default.
- W2561409078 hasConceptScore W2561409078C89423630 @default.
- W2561409078 hasConceptScore W2561409078C95444343 @default.
- W2561409078 hasLocation W25614090781 @default.
- W2561409078 hasOpenAccess W2561409078 @default.
- W2561409078 hasPrimaryLocation W25614090781 @default.
- W2561409078 hasRelatedWork W1438031802 @default.
- W2561409078 hasRelatedWork W1587261904 @default.
- W2561409078 hasRelatedWork W1997670712 @default.
- W2561409078 hasRelatedWork W2005589310 @default.
- W2561409078 hasRelatedWork W2008968208 @default.
- W2561409078 hasRelatedWork W2031757574 @default.
- W2561409078 hasRelatedWork W2036087614 @default.
- W2561409078 hasRelatedWork W2087971029 @default.
- W2561409078 hasRelatedWork W2131991514 @default.
- W2561409078 hasRelatedWork W2132973993 @default.
- W2561409078 hasRelatedWork W2141214909 @default.
- W2561409078 hasRelatedWork W2153505491 @default.
- W2561409078 hasRelatedWork W2165094253 @default.
- W2561409078 hasRelatedWork W2170840506 @default.
- W2561409078 hasRelatedWork W227920086 @default.
- W2561409078 hasRelatedWork W2401953862 @default.
- W2561409078 hasRelatedWork W2469502726 @default.
- W2561409078 hasRelatedWork W2567135579 @default.
- W2561409078 hasRelatedWork W2609117016 @default.
- W2561409078 hasRelatedWork W2883532749 @default.
- W2561409078 isParatext "false" @default.
- W2561409078 isRetracted "false" @default.
- W2561409078 magId "2561409078" @default.
- W2561409078 workType "article" @default.