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• W2561409423 abstract "Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor (WHO grade IV) with an overall survival following diagnosis of 1–2 years. GBM makes up approximately 12–15% of all intracranial tumors and the great majority (60–75%) of astrocytic tumors. Given the dismal prognosis for this malignancy, there has been an emphasis on characterizing the molecular alterations in these tumors for both prognosis and therapy. GBM development occurs due to alterations in several distinct pathways involving a combination of overexpression of growth factors and loss of apoptosis activators. Historically, GBM has been divided into two groups: primary and secondary GBM, depending primarily on age of onset and if the tumor evolved from a lower grade glioma. With the explosion of molecular testing, particularly The Cancer Genome Atlas (TCGA), GBM is now considered a collection of up to six distinct entities, that vary by global methylation pattern, chromosomal changes, and the presence or absence of groups of genetic mutations. This wealth of data has raised the possibility of better and more accurate characterization of this tumor for diagnostic, prognostic, and predictive purposes." @default.
• W2561409423 created "2017-01-06" @default.
• W2561409423 creator A5072499847 @default.
• W2561409423 date "2017-01-01" @default.
• W2561409423 modified "2023-10-16" @default.
• W2561409423 title "Molecular Testing for Glioblastoma" @default.
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• W2561409423 doi "https://doi.org/10.1016/b978-0-12-800886-7.00026-1" @default.
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