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• W2561426098 abstract "The research activity performed is addressed to the evaluation of the interaction phenomena between surgical meshes and native biological tissues and structures, with the aim to assess the biomechanical compatibility, which represents a mandatory factor for successful adoptions in different surgical procedures. The mechanical characterization of meshes for repairs is performed by means of an integrated experimental-numerical approach, in direct correlation with the surgical techniques.Surgical grafts can origin from different sources and they can be classified as synthetic or biological, characterized by peculiar biochemical and mechanical properties and, consequently, by different biomechanical performances. Biological grafts are derived from collagen-rich tissues and can be drawn from animal (xenografts) or human (allograft) sources, the latter are usually obtained from the fascial system. For this reason, the mechanical characterization of fascial tissues is performed, evaluating the in situ functional role in the interaction with surrounding biological structures. With the purpose to interpret fascial tissues mechanical behaviour, which is characterized by anisotropy, coupled geometric and material non-linearity and time-dependent phenomena, a specific fiber reinforced visco-hyperelastic model is provided. The constitutive parameters evaluation is performed through the minimization of a cost function that defines the discrepancy between experimental data and results from the model of the tensile tests. The optimization technique, based on the Simulated Annealing optimization algorithm, leads to the definition of the set of constitutive parameters to be adopted within the constitutive formulation and implemented in the model, with the purpose to achieve a suitable description of tissue in situ mechanical behaviour. The preliminary phase of fascial tissues performances is investigated through numerical analysis of the anterior compartment of the leg. The response in this region allow for a definition of the characteristic facial tissues behaviour and is of clinical interest in the several painful syndrome, as the compartment syndrome, also offering the possibility of several references in literature. As an example of xenograft, Permacol ™ is characterized through experimental analysis and constitutive modelling. It is derived from decellularized and cross-linked porcine skin and it is a graft commonly used in abdominal wall surgery.As far as synthetic meshes is concerned, Bard® Soft mesh is studied, as a lightweight, large pore monofilament polypropylene mesh, following the above mentioned procedure. The mechanical investigation of different kinds of surgical meshes is fundamental for the definition of the numerical model of the herniated and repaired human abdominal wall. The reconstruction of the abdominal region is based on MR images integrated with data from literature. Constitutive formulations of the different biological tissues of the anatomical region are provided. The numerical model allows the analysis of different configurations, firstly considering the healthy abdomen to assess its overall mechanical behaviour in physiological conditions. Then a hernia defect is introduced in the abdominal wall, with size and position defined in accordance with clinical evidences, virtually repaired by means of different kinds of grafts (biologic and synthetic). The purpose is to evaluate the mechanical interaction between native abdominal wall tissues and structures and surgical meshes, to assess the mechanical functional response and compatibility. The analysis allows the comparison between physiological and pathological conditions and between different kinds of meshes, by means of the estimation of the stress and strain fields within biological tissues and prosthesis. Attention is paid to the interaction at tissue-implant interface, providing a useful computational tool for the evaluation of surgical strategies in dependence on prosthesis configuration. The investigation entails a relevant experimental effort, essential for the extensive numerical analysis of the anatomical district considered, providing a result evaluation by direct correlation with surgical competences." @default.
• W2561426098 created "2017-01-06" @default.
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• W2561426098 date "2016-03-01" @default.
• W2561426098 modified "2023-09-24" @default.
• W2561426098 title "Integrated experimental and numerical approach to the biomechanics of surgical meshes evaluating interaction phenomena with regard to abdominal wall repair" @default.
• W2561426098 hasPublicationYear "2016" @default.
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