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• W2561439771 abstract "Epidemiological studies show low rates of diagnosed depression in men compared to women. At the same time high rates of alcohol use disorders (AUDs) and completed suicide are found among men. These data suggest that a male specific pattern for depression may exist that is linked to AUDs and suicidal behavior. To date, no underlying neuroendocrine model for this specific pattern of male depression has been suggested. In this paper we integrate findings related to this specific pattern of depression with underlying steroid secretion patterns, polymorphisms, and methylation profiles of key genes in order to detail an original neuroendocrine model of male specific depression. Low circulating levels of sex steroids seem to increase the vulnerability for male depression, while concomitant high levels of glucocorticoids further intensify this vulnerability. Interactions of hypothalamus-pituitary-gonadal (HPG) and -adrenocortical (HPA) axis related hormones seem to be highly relevant for a male specific pattern of depression linked to AUDs and suicidal behavior. Moreover, genetic variants and the epigenetic profiles of the androgen receptor gene, well-known depression related genes, and HPA axis related genes were shown to further interact with men’s steroid secretion and thus may further contribute to the proposed male specific pattern for depression. This mini-review points out the multilevel interactions between the HPG and HPA axis for a male specific pattern of depression linked to AUDs and suicidal behavior. An integration of multilevel interactions within the three hit concept of vulnerability and resilience concludes the review." @default.
• W2561439771 created "2017-01-06" @default.
• W2561439771 creator A5003565157 @default.
• W2561439771 creator A5003589137 @default.
• W2561439771 creator A5049414539 @default.
• W2561439771 creator A5051833061 @default.
• W2561439771 date "2017-01-03" @default.
• W2561439771 modified "2023-10-16" @default.
• W2561439771 title "Neuroendocrinology of a Male-Specific Pattern for Depression Linked to Alcohol Use Disorder and Suicidal Behavior" @default.
• W2561439771 cites W105445431 @default.
• W2561439771 cites W1547847868 @default.
• W2561439771 cites W1593021244 @default.
• W2561439771 cites W1621581667 @default.
• W2561439771 cites W1820796661 @default.
• W2561439771 cites W1883758818 @default.
• W2561439771 cites W1953400201 @default.
• W2561439771 cites W1969098629 @default.
• W2561439771 cites W1971175228 @default.
• W2561439771 cites W1972346109 @default.
• W2561439771 cites W1972383541 @default.
• W2561439771 cites W1974144521 @default.
• W2561439771 cites W1979532863 @default.
• W2561439771 cites W1979846675 @default.
• W2561439771 cites W1995372847 @default.
• W2561439771 cites W1996251825 @default.
• W2561439771 cites W1998261300 @default.
• W2561439771 cites W2000209446 @default.
• W2561439771 cites W2000970089 @default.
• W2561439771 cites W2001420067 @default.
• W2561439771 cites W2007186112 @default.
• W2561439771 cites W2009579074 @default.
• W2561439771 cites W2011793525 @default.
• W2561439771 cites W2013373204 @default.
• W2561439771 cites W2018844196 @default.
• W2561439771 cites W2020731053 @default.
• W2561439771 cites W2025500503 @default.
• W2561439771 cites W2029201349 @default.
• W2561439771 cites W2029526731 @default.
• W2561439771 cites W2029670390 @default.
• W2561439771 cites W2034303412 @default.
• W2561439771 cites W2036178921 @default.
• W2561439771 cites W2037050337 @default.
• W2561439771 cites W2040702176 @default.
• W2561439771 cites W2041290325 @default.
• W2561439771 cites W2042074887 @default.
• W2561439771 cites W2043227725 @default.
• W2561439771 cites W2043313558 @default.
• W2561439771 cites W2048551934 @default.
• W2561439771 cites W2051812608 @default.
• W2561439771 cites W2054422658 @default.
• W2561439771 cites W2054865325 @default.
• W2561439771 cites W2056799618 @default.
• W2561439771 cites W2060049138 @default.
• W2561439771 cites W2067573473 @default.
• W2561439771 cites W2069156312 @default.
• W2561439771 cites W2070502748 @default.
• W2561439771 cites W2072457730 @default.
• W2561439771 cites W2072528158 @default.
• W2561439771 cites W2077306993 @default.
• W2561439771 cites W2077746771 @default.
• W2561439771 cites W2080531057 @default.
• W2561439771 cites W2082720399 @default.
• W2561439771 cites W2082896138 @default.
• W2561439771 cites W2084038751 @default.
• W2561439771 cites W2087514104 @default.
• W2561439771 cites W2088068432 @default.
• W2561439771 cites W2089883957 @default.
• W2561439771 cites W2090113644 @default.
• W2561439771 cites W2105167570 @default.
• W2561439771 cites W2105168029 @default.
• W2561439771 cites W2109301274 @default.
• W2561439771 cites W2110792070 @default.
• W2561439771 cites W2117528443 @default.
• W2561439771 cites W2118210398 @default.
• W2561439771 cites W2119197433 @default.
• W2561439771 cites W2123053494 @default.
• W2561439771 cites W2127411212 @default.
• W2561439771 cites W2133924917 @default.
• W2561439771 cites W2134302159 @default.
• W2561439771 cites W2141179002 @default.
• W2561439771 cites W2144153425 @default.
• W2561439771 cites W2150581383 @default.
• W2561439771 cites W2152152795 @default.
• W2561439771 cites W2154267400 @default.
• W2561439771 cites W2157495976 @default.
• W2561439771 cites W2168412695 @default.
• W2561439771 cites W2176542148 @default.
• W2561439771 cites W2193461210 @default.
• W2561439771 cites W2275332195 @default.
• W2561439771 cites W2293639438 @default.
• W2561439771 cites W2295295945 @default.
• W2561439771 cites W2302215642 @default.
• W2561439771 cites W2304242490 @default.
• W2561439771 cites W2311884719 @default.
• W2561439771 cites W2324158400 @default.
• W2561439771 cites W2325341530 @default.
• W2561439771 cites W2334282125 @default.
• W2561439771 cites W2339233281 @default.
• W2561439771 cites W2343245455 @default.
• W2561439771 cites W2344603220 @default.

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