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• W2561457232 abstract "Parmeliaceae represents the largest and widespread family of lichens and includes species that attract much interest regarding pharmacological activities, due to their production of unique secondary metabolites. The current work aimed to investigate the in vitro antioxidant and cytotoxic activities of the methanol extracts of ten Parmeliaceae species, collected in different continents. Methanol extraction afforded high phenolic content in the extracts. The antioxidant activity displayed by lichens was evaluated through chemical assays, such as the ORAC (Oxygen Radical Absorbance Capacity) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and the ferric reducing antioxidant power (FRAP). A moderately positive correlation was found between the phenolic content and the antioxidant properties for all the species:<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:math>: 0.7430 versus ORAC values,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:math>: 0.7457 versus DPPH scavenging capacity, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:math>: 0.7056 versus FRAP reducing power. The methanol extract of Flavoparmelia euplecta exhibited the highest ORAC value, the extract of Myelochroa irrugans showed the maximum DPPH scavenging capacity, and Hypotrachyna cirrhata methanol extract demonstrated the highest reducing power. Further, the cytotoxic activity of the ten species was investigated on the human cancer cell lines HepG2 and MCF-7; Myelochroa irrugans exhibited the highest anticancer potential. The pharmacological activities shown here could be attributed to their phytochemical constituents." @default.
• W2561457232 created "2017-01-06" @default.
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• W2561457232 date "2016-01-01" @default.
• W2561457232 modified "2023-10-01" @default.
• W2561457232 title "Evaluation of the Antioxidant Capacities and Cytotoxic Effects of Ten<i>Parmeliaceae</i>Lichen Species" @default.
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• W2561457232 doi "https://doi.org/10.1155/2016/3169751" @default.
• W2561457232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5203883" @default.
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