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- W2561458712 abstract "Wnt/β-catenin signaling is activated repeatedly during an animal’s lifespan, and it controls gene expression through its essential nuclear effector, β-catenin, to regulate embryogenesis, organogenesis, and adult homeostasis. Although the β-catenin transcriptional complex has the ability to induce the expression of many genes to exert its diverse roles, it chooses and transactivates a specific gene set from among its numerous target genes depending on the context. For example, the β-catenin transcriptional complex stimulates the expression of cell cycle-related genes and consequent cell proliferation in neural progenitor cells, while it promotes the expression of neural differentiation-related genes in differentiating neurons. Recent studies using animal and cell culture models have gradually improved our understanding of the molecular basis underlying such context-dependent actions of the β-catenin transcriptional complex. Here, we describe eight mechanisms that support β-catenin-mediated context-dependent gene regulation, and their spatio-temporal regulation during vertebrate development. In addition, we discuss their contribution to the diverse functions of Wnt/β-catenin signaling." @default.
- W2561458712 created "2017-01-06" @default.
- W2561458712 creator A5038716706 @default.
- W2561458712 creator A5061243316 @default.
- W2561458712 date "2016-12-24" @default.
- W2561458712 modified "2023-10-13" @default.
- W2561458712 title "Context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling" @default.
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- W2561458712 doi "https://doi.org/10.1093/jb/mvw072" @default.
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