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- W2561459451 abstract "To investigate the role of adding chemotherapy to intensity modulated radiation therapy (IMRT) for stage II nasopharyngeal carcinoma. From May 2010 to July 2012, a total of 84 newly diagnosed stage II (American Joint Committee on Cancer 2010 stage system) nasopharyngeal carcinoma patients were entered into this study. All patients were randomized assigned to the IMRT alone group (n = 43) or the IMRT combined with concurrent cisplatin (40 mg/m2, weekly) group (CCRT group, n = 41). The primary endpoint was overall survival (OS), and the second primary endpoints were primary lesion control (PLC), regional node control (RNC), disease-free survival (DFS), distant metastasis-free survival (DMFS), and acute toxicities. With a median follow-up time of 38 months, all patients are alive. The 3-year OS, DFS, PLC, RNC, and DMFS were 100%, 94%, 96.4%, 97.6%, and 98.8%, respectively. The OS，DFS, PLC, RNC, and DMFS of the IMRT alone group and the CCRT group were 100% versus 100%, 95.3% versus 92.6% (P = .63), 97.7% versus 95.1% (P = .54), 97.7% versus 95.5% (P = 1.00), and 100% versus 97.5% (P = .31), seen in Figure 1. There were 5 patients failed during follow-up, with 2 in primary site (1 in each group), 1 in regional lymph nodes (RT group), 1 in both primary site and regional node (CCRT group), and 1 in distant metastasis (CCRT group). There was more grade 2 to 4 acute WBC toxicity in the CCRT group than in the IMRT alone group (P = .022), and no significant differences of liver, renal, skin, and oral mucositis toxicities were observed between the IMRT alone and CCRT groups. For stage II nasopharyngeal carcinoma treated by IMRT, the addition of chemotherapy does not improve treatment outcomes." @default.
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- W2561459451 date "2015-11-01" @default.
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- W2561459451 title "The Value of Adding Chemotherapy to Intensity Modulated Radiation Therapy for Stage II Nasopharyngeal Carcinoma: A Multicenter Phase 2 Study" @default.
- W2561459451 doi "https://doi.org/10.1016/j.ijrobp.2015.07.305" @default.
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