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• W2561466489 abstract "Background and Objective: Diabetes mellitus is the most common risk factor for coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) TaqIB polymorphism is associated with changes in lipid profile and may be a risk factor for CAD in patients with diabetes. This study aimed to evaluate the association of CETP TaqIB polymorphism with CAD in patients with type 2 diabetes. Methods: In this case-control study, 292 diabetic patients were divided into two groups based on angiography reports (150 participants with normal angiogram as the control group and 142 participants with more than 50% stenosis of at least one coronary artery as the case group). The CETP TaqIB genotypes were determined by PCR-RFLP analysis. Fasting blood glucose was measured using glucose oxidase and lipid profile (triglycerides, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) by an enzymatic method. Results: There was no significant difference in the frequency of genotypes and alleles between case and control group (control group: B1B1, 17.3%; B1B2, 63.3%; and B2B2, 19.3%; case group: B1B1, 18.3%; B1B2, 64.1%; and B2B2, 17.6%) (P=0.92). In the control group, subjects with heterozygous genotype (B1B2 genotype) had higher levels of cholesterol compared with the other genotypes (B1B1 and B2B2 genotypes). Also, in the case group, subjects with B1B2 genotype had significantly higher weight (P=0.013). Conclusion: There is no significant correlation between CETP TaqIB polymorphism and the increased risk of coronary artery disease in patients with type 2 diabetes." @default.
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• W2561466489 date "2015-01-01" @default.
• W2561466489 modified "2023-09-27" @default.
• W2561466489 title "Association of Cholesteryl Ester Transfer Protein-TaqIB Polymorphism with Coronary Artery Disease in Patients with Type 2 Diabetes" @default.
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