Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561478051> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2561478051 abstract "Cardiovascular calcification is often an active process involving re-differentiation of cells to an osteoblast-like phenotype, and is strongly associated with aging. Sirtuins are histone and protein deacetylases that play a critical role in a number of age-related diseases, and SIRT6-deficient mice have the most profound progeroid phenotype. The role of SIRT6 in the regulation of cardiovascular calcification, however, is poorly understood. We hypothesized that age-related reductions in sirtuins promote osteogenic differentiation in cells from aortic valve and aorta. We used aortic valve interstitial cells isolated from SIRT6-deficient mice, pigs, or humans, and vascular smooth muscle cells from mouse aorta to determine whether osteogenic differentiation of cardiovascular cells is regulated by SIRT6 levels. In line with our hypothesis, we found increased p-SMAD1/5/8 levels in cells from SIRT6-deficient aortic valve and aorta. Second, global SIRT inhibition with NAD+-depletion increased histone acetylation and protein levels of the osteogenic proteins Sp7 and Runx2. Third, inhibition of SIRTs enhanced the transcriptional responses of Sp7 and Runx2 when cells were treated with BMP2. Fourth, knockdown of SIRT6 in mouse and human aorta and aortic valve cells by RNA interference increased Sp7 expression. Finally, chronic pharmacological inhibition of SIRTs promoted calcified nodule formation and calcium deposition in cultured mouse/swine aortic valve cells. Collectively, our data suggest that reductions in SIRT6 levels favor amplification of pro-osteogenic signaling and osteogenic differentiation of cardiovascular cells and promote the formation of calcified nodules in vitro . These data also suggest that sirtuin re-activation may be a useful therapy to slow initiation and/or progression of cardiovascular calcification in vivo." @default.
- W2561478051 created "2017-01-06" @default.
- W2561478051 creator A5046881277 @default.
- W2561478051 creator A5060660422 @default.
- W2561478051 creator A5068058041 @default.
- W2561478051 creator A5090105955 @default.
- W2561478051 date "2012-05-01" @default.
- W2561478051 modified "2023-09-23" @default.
- W2561478051 title "Abstract 366: Sirtuin 6 Reduces Osteogenic Signaling in Aortic Valve Interstitial Cells and Vascular Smooth Muscle Cells" @default.
- W2561478051 doi "https://doi.org/10.1161/atvb.32.suppl_1.a366" @default.
- W2561478051 hasPublicationYear "2012" @default.
- W2561478051 type Work @default.
- W2561478051 sameAs 2561478051 @default.
- W2561478051 citedByCount "0" @default.
- W2561478051 crossrefType "journal-article" @default.
- W2561478051 hasAuthorship W2561478051A5046881277 @default.
- W2561478051 hasAuthorship W2561478051A5060660422 @default.
- W2561478051 hasAuthorship W2561478051A5068058041 @default.
- W2561478051 hasAuthorship W2561478051A5090105955 @default.
- W2561478051 hasConcept C104317684 @default.
- W2561478051 hasConcept C126322002 @default.
- W2561478051 hasConcept C127561419 @default.
- W2561478051 hasConcept C134018914 @default.
- W2561478051 hasConcept C173396325 @default.
- W2561478051 hasConcept C181199279 @default.
- W2561478051 hasConcept C185592680 @default.
- W2561478051 hasConcept C202751555 @default.
- W2561478051 hasConcept C2776363554 @default.
- W2561478051 hasConcept C2776536020 @default.
- W2561478051 hasConcept C2777595374 @default.
- W2561478051 hasConcept C2778260815 @default.
- W2561478051 hasConcept C2779395532 @default.
- W2561478051 hasConcept C2779980429 @default.
- W2561478051 hasConcept C2780309369 @default.
- W2561478051 hasConcept C2780561631 @default.
- W2561478051 hasConcept C2992686903 @default.
- W2561478051 hasConcept C502942594 @default.
- W2561478051 hasConcept C54355233 @default.
- W2561478051 hasConcept C55493867 @default.
- W2561478051 hasConcept C71924100 @default.
- W2561478051 hasConcept C75520062 @default.
- W2561478051 hasConcept C81885089 @default.
- W2561478051 hasConcept C86803240 @default.
- W2561478051 hasConcept C95444343 @default.
- W2561478051 hasConceptScore W2561478051C104317684 @default.
- W2561478051 hasConceptScore W2561478051C126322002 @default.
- W2561478051 hasConceptScore W2561478051C127561419 @default.
- W2561478051 hasConceptScore W2561478051C134018914 @default.
- W2561478051 hasConceptScore W2561478051C173396325 @default.
- W2561478051 hasConceptScore W2561478051C181199279 @default.
- W2561478051 hasConceptScore W2561478051C185592680 @default.
- W2561478051 hasConceptScore W2561478051C202751555 @default.
- W2561478051 hasConceptScore W2561478051C2776363554 @default.
- W2561478051 hasConceptScore W2561478051C2776536020 @default.
- W2561478051 hasConceptScore W2561478051C2777595374 @default.
- W2561478051 hasConceptScore W2561478051C2778260815 @default.
- W2561478051 hasConceptScore W2561478051C2779395532 @default.
- W2561478051 hasConceptScore W2561478051C2779980429 @default.
- W2561478051 hasConceptScore W2561478051C2780309369 @default.
- W2561478051 hasConceptScore W2561478051C2780561631 @default.
- W2561478051 hasConceptScore W2561478051C2992686903 @default.
- W2561478051 hasConceptScore W2561478051C502942594 @default.
- W2561478051 hasConceptScore W2561478051C54355233 @default.
- W2561478051 hasConceptScore W2561478051C55493867 @default.
- W2561478051 hasConceptScore W2561478051C71924100 @default.
- W2561478051 hasConceptScore W2561478051C75520062 @default.
- W2561478051 hasConceptScore W2561478051C81885089 @default.
- W2561478051 hasConceptScore W2561478051C86803240 @default.
- W2561478051 hasConceptScore W2561478051C95444343 @default.
- W2561478051 hasIssue "suppl_1" @default.
- W2561478051 hasLocation W25614780511 @default.
- W2561478051 hasOpenAccess W2561478051 @default.
- W2561478051 hasPrimaryLocation W25614780511 @default.
- W2561478051 hasRelatedWork W2100840634 @default.
- W2561478051 hasRelatedWork W2201739585 @default.
- W2561478051 hasRelatedWork W2561478051 @default.
- W2561478051 hasRelatedWork W3022825851 @default.
- W2561478051 hasRelatedWork W3114914894 @default.
- W2561478051 hasRelatedWork W3135261574 @default.
- W2561478051 hasRelatedWork W3212953334 @default.
- W2561478051 hasRelatedWork W4200611837 @default.
- W2561478051 hasRelatedWork W4246139191 @default.
- W2561478051 hasRelatedWork W4252056010 @default.
- W2561478051 hasVolume "32" @default.
- W2561478051 isParatext "false" @default.
- W2561478051 isRetracted "false" @default.
- W2561478051 magId "2561478051" @default.
- W2561478051 workType "article" @default.