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- W2561486703 abstract "Abstract A variety of novel 2-(substituted)- N -(4-oxo-2-phenylquinazolin-3(3 H )-yl)acetamides were synthesized by the reaction of 2-chloro- N -(4-oxo-2-phenylquinazolin-3(3 H )-yl)acetamide with various amines. The starting material, 2-chloro- N -(4-oxo-2-phenylquinazolin-3(3 H )-yl)acetamide, was synthesized from anthranilic acid by the multistep process. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. Among those, the compound 2-(ethylamino)- N -(4-oxo-2-phenylquinazolin-3(3 H )-yl)acetamide ( V9 ) showed most potent analgesic and anti-inflammatory activities of the series and it is moderately more potent compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential compared to aspirin." @default.
- W2561486703 created "2017-01-06" @default.
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- W2561486703 date "2015-08-01" @default.
- W2561486703 modified "2023-09-27" @default.
- W2561486703 title "Design and synthesis of quinazolinyl acetamides for their analgesic and anti-inflammatory activities" @default.
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- W2561486703 doi "https://doi.org/10.1515/znb-2015-0035" @default.
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