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- W2561489359 abstract "564 Objectives 68Ga-PSMA has been proposed as a promising imaging tracer for scanning prostate cancer patients at low PSA levels at which targeted salvage therapy may be effective. The aim of this study was to prospectively compare the detection rate of 68Ga-PSMA versus 11C-Choline in men with prostate cancer at biochemical recurrence (BR) using a PET/CT-MR system with a dedicated shuttle. Methods A sample of patients with PSA relapse after initial treatment was included between August and December 2015. Within 1-2 weeks a PET/CT scan was performed with 11C-Choline followed by a 68Ga-PSMA study, with an approximately dose of 400 MBq and 280 MBq, respectively, with a 64-slice PET/CT with TOF correction. For the 68Ga-PSMA scan, we used a trimodality PET/CT-MR (3.0 T) setup, aquiring MR images of the pelvis (panoramic T1-T2, multiplanar, high-resolution T2 and focal and panoramic DWI), during 30 minutes, starting 30 minutes after tracer injection. Two blinded and independent readers assessed all images. Results A total of 24 patients were enrolled of whom 13 (54%) had undergone radical prostatectomy and 11 treated with radiotherapy. The median PSA level was 4.4 ng/mL, ranging from 0.32 to 138 ng/mL. Both scans were positive in 16 patients (67%) and negative in 4 patients (17%). Three patients were positive with 68Ga-PSMA alone (12%) and one with 11C-Choline only (4%). A total of 142 lesions were detected by at least one radiopharmaceutical. We found a significantly higher SUVm for 68Ga-PSMA compared to 11C-Choline: 9.3 (2-46) versus 4.4 (1-18), median (range), for each tracer, respectively (P Conclusions In patients with prostate cancer at biochemical recurrence and low PSA level, 68Ga-PSMA detected more lesions than 11C-Choline. PET/CT-MR system is a feasible imaging modality that potentially adds clinically relevant information for patient management." @default.
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- W2561489359 date "2016-05-01" @default.
- W2561489359 modified "2023-09-24" @default.
- W2561489359 title "Prospective comparison of 11C-Choline versus 68Ga-PSMA using a tri-modality PET/CT-MR system for the diagnosis of prostate cancer patients with biochemical recurrence." @default.
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