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• W2561489434 abstract "Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers. Metabolomics is a postgenomics field that offers fresh insights for biomarkers of common complex as well as rare diseases. Using data on metabolite-disease associations published in the previous decade (2006-2016) in PubMed, ScienceDirect, Scopus, and Web of Science, we identified 101 metabolites as putative biomarkers for these three neurodegenerative diseases. Notably, uric acid, choline, creatine, L-glutamine, alanine, creatinine, and N-acetyl-L-aspartate were the shared metabolite signatures among the three diseases. The disease-metabolite-pathway associations pointed out the importance of membrane transport (through ATP binding cassette transporters), particularly of arginine and proline amino acids in all three neurodegenerative diseases. When disease-specific and common metabolic pathways were queried by using the pathway enrichment analyses, we found that alanine, aspartate, glutamate, and purine metabolism might act as alternative pathways to overcome inadequate glucose supply and energy crisis in neurodegeneration. These observations underscore the importance of metabolite-based biomarker research in deciphering the elusive pathophysiology of neurodegenerative diseases. Future research investments in metabolomics of complex diseases might provide new insights on AD, PD, and ALS that continue to place a significant burden on global health." @default.
• W2561489434 created "2017-01-06" @default.
• W2561489434 creator A5014000838 @default.
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• W2561489434 creator A5061195271 @default.
• W2561489434 date "2016-11-01" @default.
• W2561489434 modified "2023-10-06" @default.
• W2561489434 title "Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis" @default.
• W2561489434 cites W1483461884 @default.
• W2561489434 cites W1523780146 @default.
• W2561489434 cites W1588992136 @default.
• W2561489434 cites W1593967831 @default.
• W2561489434 cites W1633867298 @default.
• W2561489434 cites W1708297083 @default.
• W2561489434 cites W1836565666 @default.
• W2561489434 cites W1837152578 @default.
• W2561489434 cites W1922332827 @default.
• W2561489434 cites W1965302033 @default.
• W2561489434 cites W1965452878 @default.
• W2561489434 cites W1965558071 @default.
• W2561489434 cites W1967203590 @default.
• W2561489434 cites W1970182368 @default.
• W2561489434 cites W1971037022 @default.
• W2561489434 cites W1973232343 @default.
• W2561489434 cites W1983399491 @default.
• W2561489434 cites W1986819054 @default.
• W2561489434 cites W1994243437 @default.
• W2561489434 cites W1998271117 @default.
• W2561489434 cites W2003748133 @default.
• W2561489434 cites W2006689411 @default.
• W2561489434 cites W2006976627 @default.
• W2561489434 cites W2008312023 @default.
• W2561489434 cites W2013264191 @default.
• W2561489434 cites W2013820172 @default.
• W2561489434 cites W2014886338 @default.
• W2561489434 cites W2015623239 @default.
• W2561489434 cites W2016951305 @default.
• W2561489434 cites W2017335070 @default.
• W2561489434 cites W2022506887 @default.
• W2561489434 cites W2023122194 @default.
• W2561489434 cites W2023312191 @default.
• W2561489434 cites W2024071435 @default.
• W2561489434 cites W2028794471 @default.
• W2561489434 cites W2029122514 @default.
• W2561489434 cites W2029265723 @default.
• W2561489434 cites W2030600654 @default.
• W2561489434 cites W2031111076 @default.
• W2561489434 cites W2035357370 @default.
• W2561489434 cites W2038034523 @default.
• W2561489434 cites W2038317423 @default.
• W2561489434 cites W2040536433 @default.
• W2561489434 cites W2046429594 @default.
• W2561489434 cites W2047475836 @default.
• W2561489434 cites W2048512400 @default.
• W2561489434 cites W2050676526 @default.
• W2561489434 cites W2052585571 @default.
• W2561489434 cites W2059977526 @default.
• W2561489434 cites W2067786443 @default.
• W2561489434 cites W2072204165 @default.
• W2561489434 cites W2073778161 @default.
• W2561489434 cites W2074261703 @default.
• W2561489434 cites W2076615525 @default.
• W2561489434 cites W2077234258 @default.
• W2561489434 cites W2085686829 @default.
• W2561489434 cites W2086692662 @default.
• W2561489434 cites W2088866343 @default.
• W2561489434 cites W2089571863 @default.
• W2561489434 cites W2093363549 @default.
• W2561489434 cites W2094168427 @default.
• W2561489434 cites W2104382375 @default.
• W2561489434 cites W2106236980 @default.
• W2561489434 cites W2106731245 @default.
• W2561489434 cites W2111200377 @default.
• W2561489434 cites W2114872570 @default.
• W2561489434 cites W2120204888 @default.
• W2561489434 cites W2132485204 @default.
• W2561489434 cites W2155142785 @default.
• W2561489434 cites W2159124202 @default.
• W2561489434 cites W2159675211 @default.
• W2561489434 cites W2160061691 @default.
• W2561489434 cites W2161917727 @default.
• W2561489434 cites W2164377447 @default.
• W2561489434 cites W2166820501 @default.
• W2561489434 cites W2167543906 @default.
• W2561489434 cites W2169846859 @default.
• W2561489434 cites W2171875961 @default.
• W2561489434 cites W2172960113 @default.
• W2561489434 cites W2209246688 @default.
• W2561489434 cites W2215675716 @default.
• W2561489434 cites W2218708885 @default.
• W2561489434 cites W2224206458 @default.
• W2561489434 cites W2232323967 @default.
• W2561489434 cites W2255905287 @default.
• W2561489434 cites W2256121135 @default.
• W2561489434 cites W2257298711 @default.
• W2561489434 cites W2291857254 @default.

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