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- W2561567328 abstract "Purpose To assess if polymegethism and pleomorphism were evident in corneal endothelium after medium-term rigid gas permeable (RGP) contact lens wear. Methods In a cross-sectional observational study over 12 years, single images of the central region of the corneal endothelium of one eye of 46 subjects were taken with a non-contact specular microscope, along with a measure of central corneal thickness (CCT). The images were printed onto A3-sized paper and 100 cells/image measured by planimetry. Results Subjects aged between 20 and 32 years, with an average cumulative RGP wear of 6.0 +/− 1.6 years (range 3–9 years) were assessed; 26 of the subjects were Caucasian and 20 were Asian. The mean CCT was 0.515 +/− 0.027 mm. The group cell area value was 401 +/− 42 sq micron to give an estimated endothelial cell density (ECD) of 2520 +/− 273 cells/sq mm. As compared to a historical database, most endothelia (37/46) showed some changes with the mean coefficient of variation on cell area (COV) being 36.7 +/− 8.0% and the percentage of 6-sided (HEX) being 51.8 +/− 8.8%. There were modest correlations between years of RGP wear and both COV (p = 0.009, r spearman = 0.424) and HEX (p = 0.025, r spearman = −0.291), but not for ECD or CCT. Conclusions Corneal endothelial polymegethism appears to be a commonplace consequence of RGP lens wear with the magnitude of the change being related to the cumulative duration of the lens wear." @default.
- W2561567328 created "2017-01-06" @default.
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- W2561567328 date "2017-04-01" @default.
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- W2561567328 title "An observational cross-sectional study on the corneal endothelium of medium-term rigid gas permeable contact lens wearers" @default.
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- W2561567328 doi "https://doi.org/10.1016/j.clae.2016.12.001" @default.
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