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- W2561567457 abstract "In the symposium on Drug Effects on the Kidney held in Sidney in 1979, practically all the papers delt with various aspects of nephrotoxicity. To my knowledge, there was not a session dedicated to renal injury related to drug-induced hypersensitivity reactions. The chapters in this section address this topic, a task made very difficult by the ignorance that still persists in this area of nephropathology. During the last decade, but especially during the last 3-4 years, drug-induced hypersensitivity has received increasing attention due to its importance in clinical medicine and the accelerated pace of progress in basic research. There is evidence, based on experimental models, human disease, or both, that the four main mechanisms of hypersensitivity, namely (1) antibody reacting with renal antigens, (2) immune complex formed in situ or in the circulation, (3) cell-mediated hypersensitivity, and (4) immediate IgE-type hypersensitivity, may by activated, independently or synergistically, by drugs and that the kidney may be a target organ. The work of Tan's laboratory (Tan, 1974) has shown that the induction of autoimmune-like disease by certain drugs, such as hydralazine and procainamide, probably depends on many factors, including (in the case of lupus-like syndrome) the complexing of hydralazine with deoxyribonucleoprotein. This drug-nucleoprotein complex has been shown in vitro to resist destruction by proteolytic digestion, and in vivo this may be a mechanism for enhancing the immunogenic" @default.
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- W2561567457 date "1982-01-01" @default.
- W2561567457 modified "2023-09-27" @default.
- W2561567457 title "Drug-Induced Renal Lesions Immunopathologic Mechanisms" @default.
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