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- W2561570510 abstract "Genetic sequencing (“genotyping”) plays a critical role in the modern clinical management of HIV infection. This virus evolves rapidly within patients because of its error-prone reverse transcriptase and short generation time. Consequently, HIV variants with mutations that confer resistance to one or more antiretroviral drugs can emerge during sub-optimal treatment. There are now multiple HIV drug resistance interpretation algorithms that take the region of the HIV genome encoding the major drug targets as inputs; expert use of these algorithms can significantly improve to clinical outcomes in HIV treatment. Next-generation sequencing has the potential to revolutionize HIV resistance genotyping by lowering the threshold that rare but clinically significant HIV variants can be detected reproducibly, and by conferring improved cost-effectiveness in high-throughput scenarios. In this review, we discuss the relative merits and challenges of deploying the Illumina MiSeq instrument for clinical HIV genotyping." @default.
- W2561570510 created "2017-01-06" @default.
- W2561570510 creator A5004110504 @default.
- W2561570510 creator A5006754314 @default.
- W2561570510 date "2017-07-01" @default.
- W2561570510 modified "2023-09-29" @default.
- W2561570510 title "Promises and pitfalls of Illumina sequencing for HIV resistance genotyping" @default.
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