FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561639573> ?p ?o ?g. }

• W2561639573 endingPage "562" @default.
• W2561639573 startingPage "552" @default.
• W2561639573 abstract "Allergic asthma is a widespread chronic inflammatory disease of the airways. The role of different B cell subsets in developing asthma and respiratory tolerance is not well known. Especially regulatory B (Breg) cells are proposed to be important in asthma regulation. Using wild-type (WT) and B cell-deficient (μMT) mice we investigated how B cells are affected by induction of allergic airway inflammation and respiratory tolerance and whether they are necessary to develop these conditions. WT mice with an asthma-like phenotype, characterized by increased airway hyper reactivity, eosinophilic airway inflammation, mucus hypersecretion and elevated Th2 cytokines, exhibited increased MHCII and CD23 expression on follicular mature B cells in lung, bronchial lymph nodes (bLN) and spleen, which contributed to allergen-specific T cell proliferation in vitro. Germinal center B cell numbers were elevated and associated with increased production of allergen-specific immunoglobulins especially in bLN. In contrast, respiratory tolerance clearly attenuated these B cell alterations and directly enhanced marginal zone precursor B cells, which induced regulatory T cells in vitro. However, μMT mice developed asthma-like and tolerized phenotypes like WT mice. Our data indicate that although B cell subsets are affected by asthma-like and respiratory tolerant phenotypes, B cells are not required for tolerance induction." @default.
• W2561639573 created "2017-01-06" @default.
• W2561639573 creator A5011116502 @default.
• W2561639573 creator A5017854519 @default.
• W2561639573 creator A5070377988 @default.
• W2561639573 creator A5086637174 @default.
• W2561639573 creator A5089553231 @default.
• W2561639573 creator A5089601952 @default.
• W2561639573 date "2017-01-17" @default.
• W2561639573 modified "2023-09-24" @default.
• W2561639573 title "B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model" @default.
• W2561639573 cites W1507248048 @default.
• W2561639573 cites W1517050163 @default.
• W2561639573 cites W1527161080 @default.
• W2561639573 cites W1533266221 @default.
• W2561639573 cites W1578117262 @default.
• W2561639573 cites W1637561641 @default.
• W2561639573 cites W1882149925 @default.
• W2561639573 cites W1898108769 @default.
• W2561639573 cites W1935840505 @default.
• W2561639573 cites W1969175063 @default.
• W2561639573 cites W1970166280 @default.
• W2561639573 cites W1975630733 @default.
• W2561639573 cites W1981069511 @default.
• W2561639573 cites W1991234298 @default.
• W2561639573 cites W1994268130 @default.
• W2561639573 cites W1997714882 @default.
• W2561639573 cites W1998494804 @default.
• W2561639573 cites W2000111555 @default.
• W2561639573 cites W2000326189 @default.
• W2561639573 cites W2011969517 @default.
• W2561639573 cites W2021796121 @default.
• W2561639573 cites W2022730992 @default.
• W2561639573 cites W2031500443 @default.
• W2561639573 cites W2031972979 @default.
• W2561639573 cites W2037250871 @default.
• W2561639573 cites W2040640809 @default.
• W2561639573 cites W2041444758 @default.
• W2561639573 cites W2047940554 @default.
• W2561639573 cites W2063736745 @default.
• W2561639573 cites W2065776064 @default.
• W2561639573 cites W2072545085 @default.
• W2561639573 cites W2094486011 @default.
• W2561639573 cites W2095760150 @default.
• W2561639573 cites W2096381182 @default.
• W2561639573 cites W2098680102 @default.
• W2561639573 cites W2105969097 @default.
• W2561639573 cites W2108533902 @default.
• W2561639573 cites W2110673488 @default.
• W2561639573 cites W2116368130 @default.
• W2561639573 cites W2123257361 @default.
• W2561639573 cites W2125262390 @default.
• W2561639573 cites W2125732397 @default.
• W2561639573 cites W2131528433 @default.
• W2561639573 cites W2138302399 @default.
• W2561639573 cites W2143436758 @default.
• W2561639573 cites W2155666356 @default.
• W2561639573 cites W2155703113 @default.
• W2561639573 cites W2165283316 @default.
• W2561639573 cites W3044457927 @default.
• W2561639573 doi "https://doi.org/10.1002/eji.201646518" @default.
• W2561639573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27995616" @default.
• W2561639573 hasPublicationYear "2017" @default.
• W2561639573 type Work @default.
• W2561639573 sameAs 2561639573 @default.
• W2561639573 citedByCount "6" @default.
• W2561639573 countsByYear W25616395732017 @default.
• W2561639573 countsByYear W25616395732018 @default.
• W2561639573 countsByYear W25616395732020 @default.
• W2561639573 countsByYear W25616395732021 @default.
• W2561639573 countsByYear W25616395732023 @default.
• W2561639573 crossrefType "journal-article" @default.
• W2561639573 hasAuthorship W2561639573A5011116502 @default.
• W2561639573 hasAuthorship W2561639573A5017854519 @default.
• W2561639573 hasAuthorship W2561639573A5070377988 @default.
• W2561639573 hasAuthorship W2561639573A5086637174 @default.
• W2561639573 hasAuthorship W2561639573A5089553231 @default.
• W2561639573 hasAuthorship W2561639573A5089601952 @default.
• W2561639573 hasBestOaLocation W25616395731 @default.
• W2561639573 hasConcept C141105273 @default.
• W2561639573 hasConcept C159654299 @default.
• W2561639573 hasConcept C193419808 @default.
• W2561639573 hasConcept C203014093 @default.
• W2561639573 hasConcept C2776090121 @default.
• W2561639573 hasConcept C2776914184 @default.
• W2561639573 hasConcept C2777016536 @default.
• W2561639573 hasConcept C2778453870 @default.
• W2561639573 hasConcept C2779675166 @default.
• W2561639573 hasConcept C2781438807 @default.
• W2561639573 hasConcept C47742525 @default.
• W2561639573 hasConcept C86803240 @default.
• W2561639573 hasConcept C8891405 @default.
• W2561639573 hasConcept C96926380 @default.
• W2561639573 hasConceptScore W2561639573C141105273 @default.
• W2561639573 hasConceptScore W2561639573C159654299 @default.
• W2561639573 hasConceptScore W2561639573C193419808 @default.
• W2561639573 hasConceptScore W2561639573C203014093 @default.
• W2561639573 hasConceptScore W2561639573C2776090121 @default.

• next