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- W2561666058 abstract "We hypothesized that exertional dyspnea relief following acute bronchodilation in COPD reflects the awareness of reduced neural respiratory drive. In a randomized double-blind crossover study, 20 patients (13 men) aged 68.0±1.5 yrs (mean±SE) with GOLD stage II-IV COPD (FEV 1 =50±3% predicted) performed four 3-min stair stepping tests at 14, 16, 20 and 24 steps/min (externally paced) after inhalation of nebulized placebo or Combivent ® (500 µg ipratropium bromide/2.5 mg salbutamol). Assessments of dyspnea, ventilation (V E ), breathing pattern, dynamic operating lung volumes, crural diaphragm EMG activity (EMGdi; an index measure of neural respiratory drive), and transdiaphragmatic pressure swings (Pdi,swing) were compared between treatments at each step rate. Compared to placebo, Combivent ® improved dyspnea, breathing pattern, inspiratory capacity, inspiratory reserve volume (IRV), EMGdi and Pdi,swing at any given step rate and V E during exercise. By contrast, the relationship between exercise-induced changes in 1) EMGdi and Pdi,swing and 2) each of dyspnea, IRV and EMGdi were relatively preserved during exercise following treatment with Combivent ® vs. placebo. Exertional dyspnea relief following bronchodilation in COPD can be largely explained by the awareness of reduced neural respiratory drive (EMGdi) needed to achieve a given V E in the setting of more favorable dynamic operating lung volumes." @default.
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- W2561666058 date "2015-09-01" @default.
- W2561666058 modified "2023-09-28" @default.
- W2561666058 title "Exertional dyspnea relief following bronchodilation in COPD: Role of neural respiratory drive" @default.
- W2561666058 doi "https://doi.org/10.1183/13993003.congress-2015.pa4626" @default.
- W2561666058 hasPublicationYear "2015" @default.
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