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• W2561674325 abstract "We propose a model for the formation of chromatin loops based on the diffusive sliding of a DNA-bound factor which can dimerise to form a molecular slip-link. Our slip-links mimic the behaviour of cohesin-like molecules, which, along with the CTCF protein, stabilize loops which organize the genome. By combining 3D Brownian dynamics simulations and 1D exactly solvable non-equilibrium models, we show that diffusive sliding is sufficient to account for the strong bias in favour of convergent CTCF-mediated chromosome loops observed experimentally. Importantly, our model does not require any underlying, and energetically costly, motor activity of cohesin. We also find that the diffusive motion of multiple slip-links along chromatin may be rectified by an intriguing ratchet effect that arises if slip-links bind to the chromatin at a preferred loading site. This emergent collective behaviour is driven by a 1D osmotic pressure which is set up near the loading point, and favours the extrusion of loops which are much larger than the ones formed by single slip-links." @default.
• W2561674325 created "2017-01-06" @default.
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• W2561674325 date "2017-09-26" @default.
• W2561674325 modified "2023-10-01" @default.
• W2561674325 title "Nonequilibrium Chromosome Looping via Molecular Slip Links" @default.
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• W2561674325 doi "https://doi.org/10.1103/physrevlett.119.138101" @default.
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