FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561697259> ?p ?o ?g. }

• W2561697259 abstract "Abstract Herbal medicines usually contain a large group of chemical components, which may be transformed into more complex metabolites in vivo . In this study, we proposed a knowledge-transmitting strategy for metabolites identification of compound formulas. Gegen-Qinlian Decoction (GQD) is a classical formula in traditional Chinese medicine (TCM). It is widely used to treat diarrhea and diabetes in clinical practice. However, only tens of metabolites could be detected using conventional approaches. To comprehensively identify the metabolites of GQD, a “compound to extract to formulation” strategy was established in this study. The metabolic pathways of single representative constituents in GQD were studied, and the metabolic rules were transmitted to chemically similar compounds in herbal extracts. After screening diversified metabolites from herb extracts, the knowledge was summarized to identify the metabolites of GQD. Tandem mass spectrometry (MS n ), fragment-based scan (NL, PRE), and selected reaction monitoring (SRM) were employed to identify, screen, and monitor the metabolites, respectively. Using this strategy, we detected 131 GQD metabolites (85 were newly generated) in rats biofluids. Among them, 112 metabolites could be detected when GQD was orally administered at a clinical dosage (12.5 g/kg). This strategy could be used for systematic metabolites identification of complex Chinese medicine formulas." @default.
• W2561697259 created "2017-01-06" @default.
• W2561697259 creator A5003054073 @default.
• W2561697259 creator A5005303373 @default.
• W2561697259 creator A5006173892 @default.
• W2561697259 creator A5020494038 @default.
• W2561697259 creator A5033383729 @default.
• W2561697259 creator A5041477172 @default.
• W2561697259 creator A5042268014 @default.
• W2561697259 creator A5061537073 @default.
• W2561697259 date "2016-12-20" @default.
• W2561697259 modified "2023-10-07" @default.
• W2561697259 title "Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula" @default.
• W2561697259 cites W1988964015 @default.
• W2561697259 cites W1989472753 @default.
• W2561697259 cites W1992072482 @default.
• W2561697259 cites W1994924428 @default.
• W2561697259 cites W2002641793 @default.
• W2561697259 cites W2003198655 @default.
• W2561697259 cites W2005680114 @default.
• W2561697259 cites W2011960905 @default.
• W2561697259 cites W2014024345 @default.
• W2561697259 cites W2022444336 @default.
• W2561697259 cites W2026050956 @default.
• W2561697259 cites W2038310699 @default.
• W2561697259 cites W2057640289 @default.
• W2561697259 cites W2065442507 @default.
• W2561697259 cites W2076999434 @default.
• W2561697259 cites W2080966386 @default.
• W2561697259 cites W2088103680 @default.
• W2561697259 cites W2090559267 @default.
• W2561697259 cites W2097905994 @default.
• W2561697259 cites W2126253371 @default.
• W2561697259 cites W2130349547 @default.
• W2561697259 cites W2137621182 @default.
• W2561697259 cites W2140639123 @default.
• W2561697259 cites W2148293348 @default.
• W2561697259 cites W2149238816 @default.
• W2561697259 cites W2150810997 @default.
• W2561697259 cites W2160272757 @default.
• W2561697259 cites W2161022787 @default.
• W2561697259 cites W2171232497 @default.
• W2561697259 cites W2172063097 @default.
• W2561697259 cites W2252841720 @default.
• W2561697259 cites W2268391200 @default.
• W2561697259 cites W2315136432 @default.
• W2561697259 cites W2325523031 @default.
• W2561697259 cites W2328957967 @default.
• W2561697259 cites W2406436786 @default.
• W2561697259 cites W37094666 @default.
• W2561697259 doi "https://doi.org/10.1038/srep39534" @default.
• W2561697259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5171860" @default.
• W2561697259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27996040" @default.
• W2561697259 hasPublicationYear "2016" @default.
• W2561697259 type Work @default.
• W2561697259 sameAs 2561697259 @default.
• W2561697259 citedByCount "34" @default.
• W2561697259 countsByYear W25616972592017 @default.
• W2561697259 countsByYear W25616972592018 @default.
• W2561697259 countsByYear W25616972592019 @default.
• W2561697259 countsByYear W25616972592020 @default.
• W2561697259 countsByYear W25616972592021 @default.
• W2561697259 countsByYear W25616972592022 @default.
• W2561697259 countsByYear W25616972592023 @default.
• W2561697259 crossrefType "journal-article" @default.
• W2561697259 hasAuthorship W2561697259A5003054073 @default.
• W2561697259 hasAuthorship W2561697259A5005303373 @default.
• W2561697259 hasAuthorship W2561697259A5006173892 @default.
• W2561697259 hasAuthorship W2561697259A5020494038 @default.
• W2561697259 hasAuthorship W2561697259A5033383729 @default.
• W2561697259 hasAuthorship W2561697259A5041477172 @default.
• W2561697259 hasAuthorship W2561697259A5042268014 @default.
• W2561697259 hasAuthorship W2561697259A5061537073 @default.
• W2561697259 hasBestOaLocation W25616972591 @default.
• W2561697259 hasConcept C116834253 @default.
• W2561697259 hasConcept C142724271 @default.
• W2561697259 hasConcept C185592680 @default.
• W2561697259 hasConcept C188947578 @default.
• W2561697259 hasConcept C190409667 @default.
• W2561697259 hasConcept C204787440 @default.
• W2561697259 hasConcept C2777477808 @default.
• W2561697259 hasConcept C55493867 @default.
• W2561697259 hasConcept C556039675 @default.
• W2561697259 hasConcept C59822182 @default.
• W2561697259 hasConcept C71924100 @default.
• W2561697259 hasConcept C86803240 @default.
• W2561697259 hasConcept C98274493 @default.
• W2561697259 hasConceptScore W2561697259C116834253 @default.
• W2561697259 hasConceptScore W2561697259C142724271 @default.
• W2561697259 hasConceptScore W2561697259C185592680 @default.
• W2561697259 hasConceptScore W2561697259C188947578 @default.
• W2561697259 hasConceptScore W2561697259C190409667 @default.
• W2561697259 hasConceptScore W2561697259C204787440 @default.
• W2561697259 hasConceptScore W2561697259C2777477808 @default.
• W2561697259 hasConceptScore W2561697259C55493867 @default.
• W2561697259 hasConceptScore W2561697259C556039675 @default.
• W2561697259 hasConceptScore W2561697259C59822182 @default.
• W2561697259 hasConceptScore W2561697259C71924100 @default.
• W2561697259 hasConceptScore W2561697259C86803240 @default.
• W2561697259 hasConceptScore W2561697259C98274493 @default.

• next