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• W2561710079 abstract "Protopanaxadiol (PPD) is an active compound in Panax ginseng. Recently, an optimized PPD synthesis pathway contained a ROS releasing step (a P450-type PPD synthase, PPDS) was introduced into Saccharomyces cerevisiae. Here reported a synergistic effect of PPDS-CPR (CPR, cytochrome P450 reductase) uncoupling and ethanol stress on ROS releasing, which reduced cells viability. To build a robust strain, a cell wall integrity associated gene SSD1 was high-expressed to improve ethanol tolerance, and ROS level decreased for 24.7%. Then, regulating the expression of an oxidative stress regulation gene YBP1 decreased 75.2% of ROS releasing, and improved cells viability from 71.3 ± 1.3% to 88.3 ± 1.4% at 84 h. Increased cells viability enables yeast to produce more PPD through feeding additional ethanol. In 5 L fermenter, PPD production of W3a-ssPy reached to 4.25 ± 0.18 g/L (19.48 ± 0.28 mg/L/OD600), which is the highest yield reported so far. This work makes the industrial production of PPD possible by microbial fermentation." @default.
• W2561710079 created "2017-01-06" @default.
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• W2561710079 date "2017-03-01" @default.
• W2561710079 modified "2023-09-28" @default.
• W2561710079 title "Enhancing Saccharomyces cerevisiae reactive oxygen species and ethanol stress tolerance for high-level production of protopanoxadiol" @default.
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• W2561710079 doi "https://doi.org/10.1016/j.biortech.2016.12.061" @default.
• W2561710079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28040652" @default.
• W2561710079 hasPublicationYear "2017" @default.
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