FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561728940> ?p ?o ?g. }

• W2561728940 abstract "Over the past decades world-wide, research towards not only understanding the biology, but also attempting to decrease the mortality rate in pancreatic carcinoma has become the forefront in cancers of solid tumor. Recent evidences suggest that pancreatic carcinomas harbour a distinct subpopulation of putative cancer stem cells defined by their self-renewal capacity, differentiation ability, tumorigenicity and ability to drive towards metastasis. Therefore, there is not only a need to identify this population, and also design newer approaches to target these chemo-resistant cell populations, especially in pancreatic cancer which till date shows 5-year survival rate to be below 5%. Our study identified the potential of CD44hiCD24lo MiaPaCa2/PanC1 cells to possess lower capability to generate spheroids whereas CD44hiCD24hi MiaPaCa2/PanC1 showed higher spheroid forming capacity. Spheroids obtained from both cell-lines showed similar metastatic cancer gene expression pattern. However, a distinctive CXCR4 expression levels were observed between CD44hiCD24lo PanC1-spheroids and CD44hiCD24hi PanC1-spheroids. It was also observed that EMT, CXCR4 and Muc1 were highly expressed in MiaPaCa2-spheroids. Hence, suggesting only a sub-population of tumor cells behave as “cancer initiating cells/stem-like cells” which are associated with cell-cell adhesion and cell matrix interaction. In order to determine the role of cancer stem-like cells (spheroids/CSCs) to migrate and invade to metastasize particularly in pancreatic carcinoma, experiments were designed to evaluate their self-renewal capability and epithelial to mesenchymal transition (EMT) and their association with developmental genes. An exponential spheroid formation was observed along with stem cell transcriptional genes (Oct4 and Nanog). Interestingly, MiaPaCa2-spheroids exhibited higher expression levels of Sox-2, MMP-9 and Vimentin in comparison to PanC1-spheroids suggesting that MiaPaCa2-spheroids may be more aggressive or has higher invasive potential. It appears that pancreatic CSCs undergoing EMT probably express higher levels of Sox-9, Ngn-3, Pdx-1 and c-Myc genes which attributes to its embryonic stemness. The results from the study clearly project the role of CSCs in pancreatic carcinoma and thus further studies to delineate the mechanism which might lead to suppression of pancreatic CSCs is crucial. In this direction, a pilot study has been initiated to explore the potential of Mesenchymal Stem Cells to target the pancreatic CSCs. Citation Format: Neha Chopra, Sangeeta Choudhury, Saima Wajid, Kriti Jain, Rizwana Mirza.{Authors}. Pancreatic cancer stem cells: can it be restrained? [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr B03." @default.
• W2561728940 created "2017-01-06" @default.
• W2561728940 creator A5009394417 @default.
• W2561728940 creator A5020535312 @default.
• W2561728940 creator A5059199295 @default.
• W2561728940 creator A5063629453 @default.
• W2561728940 creator A5068465745 @default.
• W2561728940 date "2016-12-14" @default.
• W2561728940 modified "2023-09-29" @default.
• W2561728940 title "Abstract B03: Pancreatic cancer stem cells: can it be restrained?" @default.
• W2561728940 doi "https://doi.org/10.1158/1538-7445.panca16-b03" @default.
• W2561728940 hasPublicationYear "2016" @default.
• W2561728940 type Work @default.
• W2561728940 sameAs 2561728940 @default.
• W2561728940 citedByCount "0" @default.
• W2561728940 crossrefType "proceedings-article" @default.
• W2561728940 hasAuthorship W2561728940A5009394417 @default.
• W2561728940 hasAuthorship W2561728940A5020535312 @default.
• W2561728940 hasAuthorship W2561728940A5059199295 @default.
• W2561728940 hasAuthorship W2561728940A5063629453 @default.
• W2561728940 hasAuthorship W2561728940A5068465745 @default.
• W2561728940 hasConcept C121608353 @default.
• W2561728940 hasConcept C129470790 @default.
• W2561728940 hasConcept C13373296 @default.
• W2561728940 hasConcept C175369904 @default.
• W2561728940 hasConcept C203014093 @default.
• W2561728940 hasConcept C2779013556 @default.
• W2561728940 hasConcept C2780210213 @default.
• W2561728940 hasConcept C28328180 @default.
• W2561728940 hasConcept C2908647359 @default.
• W2561728940 hasConcept C502942594 @default.
• W2561728940 hasConcept C54355233 @default.
• W2561728940 hasConcept C55427017 @default.
• W2561728940 hasConcept C555283112 @default.
• W2561728940 hasConcept C71924100 @default.
• W2561728940 hasConcept C76419328 @default.
• W2561728940 hasConcept C81885089 @default.
• W2561728940 hasConcept C86803240 @default.
• W2561728940 hasConcept C8891405 @default.
• W2561728940 hasConcept C95444343 @default.
• W2561728940 hasConcept C96232424 @default.
• W2561728940 hasConcept C99454951 @default.
• W2561728940 hasConceptScore W2561728940C121608353 @default.
• W2561728940 hasConceptScore W2561728940C129470790 @default.
• W2561728940 hasConceptScore W2561728940C13373296 @default.
• W2561728940 hasConceptScore W2561728940C175369904 @default.
• W2561728940 hasConceptScore W2561728940C203014093 @default.
• W2561728940 hasConceptScore W2561728940C2779013556 @default.
• W2561728940 hasConceptScore W2561728940C2780210213 @default.
• W2561728940 hasConceptScore W2561728940C28328180 @default.
• W2561728940 hasConceptScore W2561728940C2908647359 @default.
• W2561728940 hasConceptScore W2561728940C502942594 @default.
• W2561728940 hasConceptScore W2561728940C54355233 @default.
• W2561728940 hasConceptScore W2561728940C55427017 @default.
• W2561728940 hasConceptScore W2561728940C555283112 @default.
• W2561728940 hasConceptScore W2561728940C71924100 @default.
• W2561728940 hasConceptScore W2561728940C76419328 @default.
• W2561728940 hasConceptScore W2561728940C81885089 @default.
• W2561728940 hasConceptScore W2561728940C86803240 @default.
• W2561728940 hasConceptScore W2561728940C8891405 @default.
• W2561728940 hasConceptScore W2561728940C95444343 @default.
• W2561728940 hasConceptScore W2561728940C96232424 @default.
• W2561728940 hasConceptScore W2561728940C99454951 @default.
• W2561728940 hasLocation W25617289401 @default.
• W2561728940 hasOpenAccess W2561728940 @default.
• W2561728940 hasPrimaryLocation W25617289401 @default.
• W2561728940 hasRelatedWork W1982184962 @default.
• W2561728940 hasRelatedWork W1982432361 @default.
• W2561728940 hasRelatedWork W2011847905 @default.
• W2561728940 hasRelatedWork W2028791488 @default.
• W2561728940 hasRelatedWork W2034982916 @default.
• W2561728940 hasRelatedWork W2035916711 @default.
• W2561728940 hasRelatedWork W2050577279 @default.
• W2561728940 hasRelatedWork W2058167643 @default.
• W2561728940 hasRelatedWork W2058400226 @default.
• W2561728940 hasRelatedWork W2060415235 @default.
• W2561728940 hasRelatedWork W2083646121 @default.
• W2561728940 hasRelatedWork W2105706830 @default.
• W2561728940 hasRelatedWork W2120489158 @default.
• W2561728940 hasRelatedWork W2122806383 @default.
• W2561728940 hasRelatedWork W2322593464 @default.
• W2561728940 hasRelatedWork W2333330507 @default.
• W2561728940 hasRelatedWork W2478994845 @default.
• W2561728940 hasRelatedWork W2562586427 @default.
• W2561728940 hasRelatedWork W2757918906 @default.
• W2561728940 hasRelatedWork W2980552249 @default.
• W2561728940 isParatext "false" @default.
• W2561728940 isRetracted "false" @default.
• W2561728940 magId "2561728940" @default.
• W2561728940 workType "article" @default.