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- W2561743930 abstract "Introduction: A phase 2 study of eculizumab for treating myasthenia gravis (MG) used the quantitative myasthenia gravis score (QMG) and myasthenia gravis activities of daily living profile (MG-ADL) to evaluate baseline disease severity and treatment response. Correlations were then analyzed between these assessments. Methods Patients were given eculizumab or placebo during the first 16-week treatment period of the crossover study, with treatment assignments reversed for the second treatment period following a 5-week washout. QMG and MG-ADL scores at baseline and endpoint of each treatment period generated correlation coefficients for baseline status and treatment response during eculizumab therapy. Results Correlation strength between QMG and MG-ADL scores was higher for treatment response (R = 0.726; 95% confidence interval, 0.264-0.907; P = 0.0036) than for assessing baseline disease status (R = 0.552; 95% confidence interval, –0.022-0.839; P = 0.0495). Conclusions MG-ADL may be more sensitive for assessing treatment response than point-in-time disease status. Muscle Nerve 56: 328–330, 2017" @default.
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- W2561743930 date "2017-02-25" @default.
- W2561743930 modified "2023-10-02" @default.
- W2561743930 title "QMG and MG-ADL correlations: Study of eculizumab treatment of myasthenia gravis" @default.
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- W2561743930 doi "https://doi.org/10.1002/mus.25529" @default.
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