Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561744811> ?p ?o ?g. }
- W2561744811 endingPage "e986" @default.
- W2561744811 startingPage "e986" @default.
- W2561744811 abstract "Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment has been paralleled by the high incidence of acute and chronic neuropsychiatric side effects, which reinforces the brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation (long-term potentiation, LTP) or depotentiation (long-term depression, LTD) of synaptic transmission efficacy, and the phosphorylation state of Ser831 and Ser845 sites, in the GluA1 subunit of the glutamate AMPA receptors, are a critical event for these synaptic neuroplasticity events. Through a quasi-randomized controlled study, we show that a single high dexamethasone dose significantly reduces in a dose-dependent manner the levels of GluA1-Ser831 phosphorylation in the amygdala resected during surgery for temporal lobe epilepsy. This is the first report demonstrating GC effects on key markers of synaptic neuroplasticity in the human limbic system. The results contribute to understanding how GC affects the human brain under physiologic and pharmacologic conditions." @default.
- W2561744811 created "2017-01-06" @default.
- W2561744811 creator A5017555495 @default.
- W2561744811 creator A5017571758 @default.
- W2561744811 creator A5025886672 @default.
- W2561744811 creator A5026369247 @default.
- W2561744811 creator A5033851963 @default.
- W2561744811 creator A5036700773 @default.
- W2561744811 creator A5036963787 @default.
- W2561744811 creator A5037557415 @default.
- W2561744811 creator A5051074734 @default.
- W2561744811 creator A5056338380 @default.
- W2561744811 creator A5059479762 @default.
- W2561744811 creator A5063309884 @default.
- W2561744811 creator A5065688344 @default.
- W2561744811 creator A5076334811 @default.
- W2561744811 creator A5077779135 @default.
- W2561744811 date "2016-12-13" @default.
- W2561744811 modified "2023-10-06" @default.
- W2561744811 title "A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system" @default.
- W2561744811 cites W1609834322 @default.
- W2561744811 cites W1633023755 @default.
- W2561744811 cites W1824821999 @default.
- W2561744811 cites W1919848305 @default.
- W2561744811 cites W1972710070 @default.
- W2561744811 cites W1973832107 @default.
- W2561744811 cites W1979231658 @default.
- W2561744811 cites W1980185032 @default.
- W2561744811 cites W1980736134 @default.
- W2561744811 cites W1982864908 @default.
- W2561744811 cites W1983645757 @default.
- W2561744811 cites W1987207402 @default.
- W2561744811 cites W1989732373 @default.
- W2561744811 cites W1993135690 @default.
- W2561744811 cites W2000563504 @default.
- W2561744811 cites W2001934289 @default.
- W2561744811 cites W2002551520 @default.
- W2561744811 cites W2008291191 @default.
- W2561744811 cites W2011560428 @default.
- W2561744811 cites W2016575029 @default.
- W2561744811 cites W2016909901 @default.
- W2561744811 cites W2019806256 @default.
- W2561744811 cites W2020709072 @default.
- W2561744811 cites W2020897240 @default.
- W2561744811 cites W2023648659 @default.
- W2561744811 cites W2025468569 @default.
- W2561744811 cites W2027066838 @default.
- W2561744811 cites W2030976437 @default.
- W2561744811 cites W2034493924 @default.
- W2561744811 cites W2043247184 @default.
- W2561744811 cites W2043487837 @default.
- W2561744811 cites W2044686824 @default.
- W2561744811 cites W2045176281 @default.
- W2561744811 cites W2047470842 @default.
- W2561744811 cites W2049511526 @default.
- W2561744811 cites W2060790609 @default.
- W2561744811 cites W2066003939 @default.
- W2561744811 cites W2069121592 @default.
- W2561744811 cites W2071256705 @default.
- W2561744811 cites W2071279191 @default.
- W2561744811 cites W2077086070 @default.
- W2561744811 cites W2080640632 @default.
- W2561744811 cites W2081511210 @default.
- W2561744811 cites W2092427441 @default.
- W2561744811 cites W2095484045 @default.
- W2561744811 cites W2102131116 @default.
- W2561744811 cites W2102967434 @default.
- W2561744811 cites W2112354679 @default.
- W2561744811 cites W2112374693 @default.
- W2561744811 cites W2118697382 @default.
- W2561744811 cites W2123067258 @default.
- W2561744811 cites W2130672560 @default.
- W2561744811 cites W2130907973 @default.
- W2561744811 cites W2141747860 @default.
- W2561744811 cites W2143204630 @default.
- W2561744811 cites W2148389554 @default.
- W2561744811 cites W2151027504 @default.
- W2561744811 cites W2156468266 @default.
- W2561744811 cites W2159570634 @default.
- W2561744811 cites W2168319429 @default.
- W2561744811 cites W2174242249 @default.
- W2561744811 cites W2178106250 @default.
- W2561744811 cites W2233343952 @default.
- W2561744811 cites W2236053794 @default.
- W2561744811 cites W2269418869 @default.
- W2561744811 cites W2276347070 @default.
- W2561744811 cites W2291443053 @default.
- W2561744811 cites W229974552 @default.
- W2561744811 cites W2317495993 @default.
- W2561744811 cites W2328153812 @default.
- W2561744811 cites W2335243640 @default.
- W2561744811 cites W2335818909 @default.
- W2561744811 cites W2418351874 @default.
- W2561744811 cites W2504559731 @default.
- W2561744811 cites W2598441763 @default.
- W2561744811 doi "https://doi.org/10.1038/tp.2016.251" @default.
- W2561744811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5290343" @default.
- W2561744811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27959333" @default.