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- W2561763247 abstract "The cellular and molecular bases of neurological diseases have been studied for decades; however, the underlying mechanisms are not yet fully elucidated. Compared with other disorders, diseases of the nervous system have been very difficult to study mainly due to the inaccessibility of the human brain and live neurons in vivo or in vitro and difficulties in examination of human postmortem brain tissue. Despite the availability of various genetically engineered animal models, these systems are still not adequate enough due to species variation and differences in genetic background. Human induced pluripotent stem cells (hiPSCs) reprogrammed from patient somatic cells possess the potential to differentiate into any cell type, including neural progenitor cells and postmitotic neurons; thus, they open a new area to in vitro modeling of neurological diseases and their potential treatment. Currently, many protocols for generation of various neuronal subtypes are being developed; however, most of them still require further optimization. Here, we highlight accomplishments made in the generation of dopaminergic and cholinergic neurons, the two subtypes most affected in Alzheimer's and Parkinson's diseases and indirectly affected in Huntington's disease. Furthermore, we discuss the potential role of hiPSC-derived neurons in the modeling and treatment of neurological diseases related to dopaminergic and cholinergic system dysfunction." @default.
- W2561763247 created "2017-01-06" @default.
- W2561763247 creator A5021811939 @default.
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- W2561763247 creator A5058583468 @default.
- W2561763247 creator A5084214493 @default.
- W2561763247 date "2016-01-01" @default.
- W2561763247 modified "2023-10-07" @default.
- W2561763247 title "Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy" @default.
- W2561763247 cites W1489178621 @default.
- W2561763247 cites W1503301128 @default.
- W2561763247 cites W1572301294 @default.
- W2561763247 cites W1592647647 @default.
- W2561763247 cites W1816679421 @default.
- W2561763247 cites W1832914678 @default.
- W2561763247 cites W1965816119 @default.
- W2561763247 cites W1966476278 @default.
- W2561763247 cites W1971637333 @default.
- W2561763247 cites W1972305852 @default.
- W2561763247 cites W1978354427 @default.
- W2561763247 cites W1980505651 @default.
- W2561763247 cites W1981437331 @default.
- W2561763247 cites W1983274440 @default.
- W2561763247 cites W1989151396 @default.
- W2561763247 cites W1989211762 @default.
- W2561763247 cites W1995626795 @default.
- W2561763247 cites W1998946448 @default.
- W2561763247 cites W2000072223 @default.
- W2561763247 cites W2003126320 @default.
- W2561763247 cites W2003774068 @default.
- W2561763247 cites W2004155733 @default.
- W2561763247 cites W2005483591 @default.
- W2561763247 cites W2006102445 @default.
- W2561763247 cites W2007535582 @default.
- W2561763247 cites W2008468014 @default.
- W2561763247 cites W2010369463 @default.
- W2561763247 cites W2010478595 @default.
- W2561763247 cites W2012423618 @default.
- W2561763247 cites W2019019227 @default.
- W2561763247 cites W2035000249 @default.
- W2561763247 cites W2037438288 @default.
- W2561763247 cites W2037922669 @default.
- W2561763247 cites W2043655216 @default.
- W2561763247 cites W2045065424 @default.
- W2561763247 cites W2045821289 @default.
- W2561763247 cites W2049230645 @default.
- W2561763247 cites W2062790445 @default.
- W2561763247 cites W2063156659 @default.
- W2561763247 cites W2064993589 @default.
- W2561763247 cites W2067318929 @default.
- W2561763247 cites W2068434142 @default.
- W2561763247 cites W2068654563 @default.
- W2561763247 cites W2070269121 @default.
- W2561763247 cites W2072347113 @default.
- W2561763247 cites W2076412273 @default.
- W2561763247 cites W2079749054 @default.
- W2561763247 cites W2083939751 @default.
- W2561763247 cites W2085164313 @default.
- W2561763247 cites W2086046051 @default.
- W2561763247 cites W2086943348 @default.
- W2561763247 cites W2087598124 @default.
- W2561763247 cites W2087786585 @default.
- W2561763247 cites W2088714934 @default.
- W2561763247 cites W2091134679 @default.
- W2561763247 cites W2096973446 @default.
- W2561763247 cites W2097087191 @default.
- W2561763247 cites W2099548919 @default.
- W2561763247 cites W2103540918 @default.
- W2561763247 cites W2103612759 @default.
- W2561763247 cites W2105352010 @default.
- W2561763247 cites W2111191613 @default.
- W2561763247 cites W2119508244 @default.
- W2561763247 cites W2125991715 @default.
- W2561763247 cites W2126774748 @default.
- W2561763247 cites W2127330296 @default.
- W2561763247 cites W2129879513 @default.
- W2561763247 cites W2130128490 @default.
- W2561763247 cites W2131108668 @default.
- W2561763247 cites W2131321387 @default.
- W2561763247 cites W2132765435 @default.
- W2561763247 cites W2134964344 @default.
- W2561763247 cites W2136440581 @default.
- W2561763247 cites W2137607857 @default.
- W2561763247 cites W2138574694 @default.
- W2561763247 cites W2138977668 @default.
- W2561763247 cites W2143515674 @default.
- W2561763247 cites W2145492799 @default.
- W2561763247 cites W2146890924 @default.
- W2561763247 cites W2146893133 @default.
- W2561763247 cites W2147061679 @default.
- W2561763247 cites W2157073241 @default.
- W2561763247 cites W2157142964 @default.
- W2561763247 cites W2157645703 @default.
- W2561763247 cites W2162811821 @default.
- W2561763247 cites W2163318434 @default.
- W2561763247 cites W2164228391 @default.
- W2561763247 cites W2165028896 @default.