FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2561858807> ?p ?o ?g. }

• W2561858807 abstract "The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date. Here we report a genome survey of 3,400 actinomycetes, identifying 81 strains that harbor genes encoding the enediyne polyketide synthase cassettes that could be grouped into 28 distinct clades based on phylogenetic analysis. Genome sequencing of 31 representative strains confirmed that each clade harbors a distinct enediyne biosynthetic gene cluster. A genome neighborhood network allows prediction of new structural features and biosynthetic insights that could be exploited for enediyne discovery. We confirmed one clade as new C-1027 producers, with a significantly higher C-1027 titer than the original producer, and discovered a new family of enediyne natural products, the tiancimycins (TNMs), that exhibit potent cytotoxicity against a broad spectrum of cancer cell lines. Our results demonstrate the feasibility of rapid discovery of new enediynes from a large strain collection.Recent advances in microbial genomics clearly revealed that the biosynthetic potential of soil actinomycetes to produce enediynes is underappreciated. A great challenge is to develop innovative methods to discover new enediynes and produce them in sufficient quantities for chemical, biological, and clinical investigations. This work demonstrated the feasibility of rapid discovery of new enediynes from a large strain collection. The new C-1027 producers, with a significantly higher C-1027 titer than the original producer, will impact the practical supply of this important drug lead. The TNMs, with their extremely potent cytotoxicity against various cancer cells and their rapid and complete cancer cell killing characteristics, in comparison with the payloads used in FDA-approved antibody-drug conjugates (ADCs), are poised to be exploited as payload candidates for the next generation of anticancer ADCs. Follow-up studies on the other identified hits promise the discovery of new enediynes, radically expanding the chemical space for the enediyne family." @default.
• W2561858807 created "2017-01-06" @default.
• W2561858807 creator A5006608040 @default.
• W2561858807 creator A5023695700 @default.
• W2561858807 creator A5032968619 @default.
• W2561858807 creator A5035076570 @default.
• W2561858807 creator A5035580389 @default.
• W2561858807 creator A5048194874 @default.
• W2561858807 creator A5060769915 @default.
• W2561858807 creator A5061873699 @default.
• W2561858807 creator A5064871447 @default.
• W2561858807 creator A5065812703 @default.
• W2561858807 creator A5066162156 @default.
• W2561858807 creator A5069338545 @default.
• W2561858807 creator A5072029578 @default.
• W2561858807 creator A5075562803 @default.
• W2561858807 creator A5080271103 @default.
• W2561858807 creator A5082756197 @default.
• W2561858807 creator A5086517122 @default.
• W2561858807 creator A5087514362 @default.
• W2561858807 creator A5088703372 @default.
• W2561858807 date "2016-12-30" @default.
• W2561858807 modified "2023-10-16" @default.
• W2561858807 title "Strain Prioritization and Genome Mining for Enediyne Natural Products" @default.
• W2561858807 cites W1266258446 @default.
• W2561858807 cites W1557340160 @default.
• W2561858807 cites W1653566113 @default.
• W2561858807 cites W1933115513 @default.
• W2561858807 cites W1972189514 @default.
• W2561858807 cites W1972669360 @default.
• W2561858807 cites W1975528208 @default.
• W2561858807 cites W1978911837 @default.
• W2561858807 cites W1984290843 @default.
• W2561858807 cites W1998278019 @default.
• W2561858807 cites W1999546902 @default.
• W2561858807 cites W2002711269 @default.
• W2561858807 cites W2009257824 @default.
• W2561858807 cites W2014286596 @default.
• W2561858807 cites W2023950913 @default.
• W2561858807 cites W2027739380 @default.
• W2561858807 cites W2036561818 @default.
• W2561858807 cites W2038979178 @default.
• W2561858807 cites W2041884436 @default.
• W2561858807 cites W2044504370 @default.
• W2561858807 cites W2070363332 @default.
• W2561858807 cites W2082529739 @default.
• W2561858807 cites W2083061683 @default.
• W2561858807 cites W2088808945 @default.
• W2561858807 cites W2091767127 @default.
• W2561858807 cites W2108720146 @default.
• W2561858807 cites W2121938728 @default.
• W2561858807 cites W2124514746 @default.
• W2561858807 cites W2129744420 @default.
• W2561858807 cites W2134225148 @default.
• W2561858807 cites W2135784871 @default.
• W2561858807 cites W2136520405 @default.
• W2561858807 cites W2149779144 @default.
• W2561858807 cites W2153554955 @default.
• W2561858807 cites W2158779760 @default.
• W2561858807 cites W2159675211 @default.
• W2561858807 cites W2163851812 @default.
• W2561858807 cites W2165168809 @default.
• W2561858807 cites W2179836657 @default.
• W2561858807 cites W2185500533 @default.
• W2561858807 cites W2294824523 @default.
• W2561858807 cites W2319108096 @default.
• W2561858807 cites W2319134851 @default.
• W2561858807 cites W2320823775 @default.
• W2561858807 cites W2409033594 @default.
• W2561858807 cites W2434559458 @default.
• W2561858807 cites W2505382197 @default.
• W2561858807 cites W4234175205 @default.
• W2561858807 cites W4244592063 @default.
• W2561858807 doi "https://doi.org/10.1128/mbio.02104-16" @default.
• W2561858807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5181780" @default.
• W2561858807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27999165" @default.
• W2561858807 hasPublicationYear "2016" @default.
• W2561858807 type Work @default.
• W2561858807 sameAs 2561858807 @default.
• W2561858807 citedByCount "78" @default.
• W2561858807 countsByYear W25618588072017 @default.
• W2561858807 countsByYear W25618588072018 @default.
• W2561858807 countsByYear W25618588072019 @default.
• W2561858807 countsByYear W25618588072020 @default.
• W2561858807 countsByYear W25618588072021 @default.
• W2561858807 countsByYear W25618588072022 @default.
• W2561858807 countsByYear W25618588072023 @default.
• W2561858807 crossrefType "journal-article" @default.
• W2561858807 hasAuthorship W2561858807A5006608040 @default.
• W2561858807 hasAuthorship W2561858807A5023695700 @default.
• W2561858807 hasAuthorship W2561858807A5032968619 @default.
• W2561858807 hasAuthorship W2561858807A5035076570 @default.
• W2561858807 hasAuthorship W2561858807A5035580389 @default.
• W2561858807 hasAuthorship W2561858807A5048194874 @default.
• W2561858807 hasAuthorship W2561858807A5060769915 @default.
• W2561858807 hasAuthorship W2561858807A5061873699 @default.
• W2561858807 hasAuthorship W2561858807A5064871447 @default.
• W2561858807 hasAuthorship W2561858807A5065812703 @default.
• W2561858807 hasAuthorship W2561858807A5066162156 @default.
• W2561858807 hasAuthorship W2561858807A5069338545 @default.

• next