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- W2562006265 abstract "Rats were injected intraperitoneally once every 12 h with 10 mg/kg delta-9-THC and the time course of the depressant effect was determined after one and nine injections. The motor activity of naive rats was maximally depressed between 1 and 4 h and returned to control levels 8 h after treatment. After nine injections, the maximum intensity of the depres- sant effect was not different from that after one injec- tion but had completely disappeared at an earlier time point (4 h p.i.) indicating the development of tolerance to the duration of effect on motor activity. The subcellular distribution studies in brains of tolerant and non-tolerant rats indicated that an accelarated shift in the concentrations of delta-9-THC and 11-OH-delta-9-THC towards highly polar metab- olites in the brains, rather than an increased elimina- tion of these cannabinoids or decreased sensitivity of the brain may be responsible for the development of tolerance to delta-9-THC." @default.
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- W2562006265 date "1977-01-01" @default.
- W2562006265 modified "2023-09-27" @default.
- W2562006265 title "The Subcellular Distribution of Delta-9-Tetrahyd rocannabinol and Its Metabolites in Brains of Tolerant and Non-Tolerant Rats" @default.
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