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- W2562034885 abstract "Introduction: Neonatal septicemia can be described as, systemic bacterial infection in neonates documented by positive blood culture. Neonatal septicemia is a major cause of morbidity and mortality among the neonates. It may be classified on the basis of onset of sepsis, 3-28 days as late onset sepsis (LOS). EOS and LOS are caused by organisms that are prevalent in the maternal genital tract and environmental factors, respectively. Materials and Methods: Venous blood was collected aseptically and inoculated in the blood culture bottle. Further isolation and identification was done by Standard Microbiological Guidelines. Antibiotic susceptibility was detected according to CLSI guidelines. Results: In our study, out of 388 clinically suspected septicemic neonatal cases, 140 (36.08%) was blood culture positive. In our study, out of 140 positive blood culture, 92 (65.71%) were males and 48 (34.29%) were female. Among positive blood culture 97 (69.29%) were EOS and 43 (30.71%) were LOS and out of 140 positive blood culture 83 (59.29%) were Gram-positive organism and 57 (40.71%) were Gram-negative organisms. In our study, the most common organism was Staphylococcus aureus 60 (42.85%) and Klebsiella pneumoniae 23 (16.43%) was a second most common causative organism of neonatal septicemia. Among Gram-positive organism, the most sensitive antibiotic was vancomycin 80 (96.39%) and linzolid 72 (86.74%). Among Gram-negative organism, the most sensitive antibiotic was polymyxin B (87.71%) and chloramphenicol, tigecycline, and meropenem (27.36%). Conclusion: S. aureus is the most common Gram-positive bacterium, and Klebsiella is the most common Gram-negative bacterium causing neonatal sepsis. There is an increasing trend of antibiotic resistance against the commonly used first-line drugs. Continuous surveillance of antibiotic susceptibility is needed to ensure proper empirical therapy." @default.
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- W2562034885 date "2016-01-01" @default.
- W2562034885 modified "2023-09-23" @default.
- W2562034885 title "Isolation of Pathogenic Aerobic Organism from the Blood of Septicemic Neonates and the Susceptibility of Isolates to Various Antibiotics Attending in TMMC & RC, Moradabad, India" @default.
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