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- W25621069 abstract "Human tumor viruses are members of distinct taxonomic groups that are causally linked to malignant diseases, which develop from transformed infected cells. They include the high-risk human papillomaviruses (HPV), a hepadnavirus (hepatitis B virus, HBV), a flavivirus (hepatitis C virus, HCV), a retrovirus (human T-cell leukemia virus type 1, HTLV-1), and two herpesviruses (Epstein–Barr virus, EBV; Kaposi's sarcoma-associated herpesvirus, KSHV). The most frequent virus-induced malignancies originate from epithelia as genital carcinomas (HPV16, 18, etc.), the viral hepatocellular carcinoma (HBV, HCV), or the nasopharyngeal carcinoma (EBV). A second major target of tumor virus-mediated oncogenesis are hematopoetic cells. Lymphomas in immunosuppressed individuals (EBV), Hodgkin's lymphoma (EBV), Burkitt's lymphoma (EBV), multicentric Castleman's disease (KSHV), primary effusion lymphoma (KSHV), and adult T-cell leukemia/lymphoma (HTLV-1) are diseases that develop from the lymphoid lineage. Most virally induced malignancies develop after long periods of persistent infection in a minority of the infected individuals, indicating the requirement of rare additional events in oncogenesis. Since all human tumor viruses are important or necessary for the development of particular cancers, these cancers are, in principle, preventable by protective immunization." @default.
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- W25621069 date "2008-01-01" @default.
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- W25621069 title "Tumor Viruses: Human" @default.
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