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- W2562114518 abstract "Abstract Background: The study aimed to evaluate the relationship of paraoxonase 2 ( PON2 ) gene Cys311Ser variants with blood pressure values, endothelial/hemostatic marker levels, and other laboratory parameters in asymptomatic dyslipidemic subjects. The same analyses were also performed with the common variants of PON2 Cys311Ser and –T1131C apolipoprotein A5 ( ApoA5 ) polymorphisms, and PON2 Cys311Ser and apolipoprotein E ( ApoE ) polymorphisms. Methods: Two hundred and sixty-four individuals were included in the study. The laboratory parameters were assessed by routine kit methods, while methods based on polymerase chain reaction were used for PON2 , ApoA5 , and ApoE genotyping. Results: PON2 311 SS homozygous individuals had significantly lower systolic blood pressure values (SBP, p<0.01), C-reactive protein, and apolipoprotein A1 levels (p<0.05), as compared with C allele carriers. The analysis revealed no differences in the levels of endothelial/hemostatic markers, except for the increased adhesion molecule [soluble vascular cell adhesion molecule 1 (sVCAM-1)] concentrations in 311S/E2 carriers (p<0.05). PON2 311S subjects showed the lowest values of SBP in combination with “neutral” ApoE3 allele (p<0.05). Conclusions: The presence of the PON2 311 C variant could represent an elevated risk of atherosclerotic complications in asymptomatic dyslipidemic individuals. Nevertheless, considering the study limitations, these relationships are necessary to be confirmed in further research." @default.
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- W2562114518 date "2015-06-26" @default.
- W2562114518 modified "2023-10-17" @default.
- W2562114518 title "Paraoxonase 2 Cys311Ser polymorphism and its association with the systolic blood pressure values in asymptomatic dyslipidemic individuals: a pilot study" @default.
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- W2562114518 doi "https://doi.org/10.1515/labmed-2015-0009" @default.
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