Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562165708> ?p ?o ?g. }
- W2562165708 endingPage "876" @default.
- W2562165708 startingPage "865" @default.
- W2562165708 abstract "ABSTRACT The diarrheal pathogen Clostridium difficile consists of at least six distinct evolutionary lineages. The RT017 lineage is anomalous, as strains only express toxin B, compared to strains from other lineages that produce toxins A and B and, occasionally, binary toxin. Historically, RT017 initially was reported in Asia but now has been reported worldwide. We used whole-genome sequencing and phylogenetic analysis to investigate the patterns of global spread and population structure of 277 RT017 isolates from animal and human origins from six continents, isolated between 1990 and 2013. We reveal two distinct evenly split sublineages (SL1 and SL2) of C. difficile RT017 that contain multiple independent clonal expansions. All 24 animal isolates were contained within SL1 along with human isolates, suggesting potential transmission between animals and humans. Genetic analyses revealed an overrepresentation of antibiotic resistance genes. Phylogeographic analyses show a North American origin for RT017, as has been found for the recently emerged epidemic RT027 lineage. Despite having only one toxin, RT017 strains have evolved in parallel from at least two independent sources and can readily transmit between continents." @default.
- W2562165708 created "2017-01-06" @default.
- W2562165708 creator A5000374291 @default.
- W2562165708 creator A5002008542 @default.
- W2562165708 creator A5002284726 @default.
- W2562165708 creator A5002465187 @default.
- W2562165708 creator A5020530889 @default.
- W2562165708 creator A5023116254 @default.
- W2562165708 creator A5026816951 @default.
- W2562165708 creator A5032142800 @default.
- W2562165708 creator A5035710161 @default.
- W2562165708 creator A5041987249 @default.
- W2562165708 creator A5044678802 @default.
- W2562165708 creator A5050926913 @default.
- W2562165708 creator A5052440667 @default.
- W2562165708 creator A5066925737 @default.
- W2562165708 creator A5069726087 @default.
- W2562165708 creator A5069991592 @default.
- W2562165708 creator A5079044997 @default.
- W2562165708 creator A5091709037 @default.
- W2562165708 date "2017-03-01" @default.
- W2562165708 modified "2023-09-27" @default.
- W2562165708 title "Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages" @default.
- W2562165708 cites W1874334284 @default.
- W2562165708 cites W1882758048 @default.
- W2562165708 cites W1898462148 @default.
- W2562165708 cites W190032426 @default.
- W2562165708 cites W1910760255 @default.
- W2562165708 cites W192965100 @default.
- W2562165708 cites W194974730 @default.
- W2562165708 cites W1965153807 @default.
- W2562165708 cites W1965863157 @default.
- W2562165708 cites W1973864798 @default.
- W2562165708 cites W1980030331 @default.
- W2562165708 cites W1989018962 @default.
- W2562165708 cites W1993888460 @default.
- W2562165708 cites W1999817070 @default.
- W2562165708 cites W2000409727 @default.
- W2562165708 cites W2003466319 @default.
- W2562165708 cites W2006374464 @default.
- W2562165708 cites W2011832962 @default.
- W2562165708 cites W2024307156 @default.
- W2562165708 cites W2028296879 @default.
- W2562165708 cites W2035955155 @default.
- W2562165708 cites W2050842460 @default.
- W2562165708 cites W2051223662 @default.
- W2562165708 cites W2058806113 @default.
- W2562165708 cites W2059278858 @default.
- W2562165708 cites W2067250990 @default.
- W2562165708 cites W2079200451 @default.
- W2562165708 cites W2080818950 @default.
- W2562165708 cites W2083793985 @default.
- W2562165708 cites W2093116438 @default.
- W2562165708 cites W2096093282 @default.
- W2562165708 cites W2102459023 @default.
- W2562165708 cites W2103441770 @default.
- W2562165708 cites W2106583741 @default.
- W2562165708 cites W2108234281 @default.
- W2562165708 cites W2112548067 @default.
- W2562165708 cites W2112619770 @default.
- W2562165708 cites W2112802172 @default.
- W2562165708 cites W2113607780 @default.
- W2562165708 cites W2113721855 @default.
- W2562165708 cites W2118200177 @default.
- W2562165708 cites W2124954746 @default.
- W2562165708 cites W2128757992 @default.
- W2562165708 cites W2130362098 @default.
- W2562165708 cites W2130619690 @default.
- W2562165708 cites W2131271579 @default.
- W2562165708 cites W2132963724 @default.
- W2562165708 cites W2135913675 @default.
- W2562165708 cites W2139293192 @default.
- W2562165708 cites W2140497101 @default.
- W2562165708 cites W2141052558 @default.
- W2562165708 cites W2141982493 @default.
- W2562165708 cites W2142113823 @default.
- W2562165708 cites W2145400118 @default.
- W2562165708 cites W2155589911 @default.
- W2562165708 cites W2158515313 @default.
- W2562165708 cites W2161501189 @default.
- W2562165708 cites W2161990844 @default.
- W2562165708 cites W2162304219 @default.
- W2562165708 cites W2168200296 @default.
- W2562165708 cites W2169794659 @default.
- W2562165708 cites W2218118400 @default.
- W2562165708 cites W2265543965 @default.
- W2562165708 cites W2416347680 @default.
- W2562165708 cites W277714373 @default.
- W2562165708 cites W98225939 @default.
- W2562165708 doi "https://doi.org/10.1128/jcm.01296-16" @default.
- W2562165708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5328454" @default.
- W2562165708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28031436" @default.
- W2562165708 hasPublicationYear "2017" @default.
- W2562165708 type Work @default.
- W2562165708 sameAs 2562165708 @default.
- W2562165708 citedByCount "47" @default.
- W2562165708 countsByYear W25621657082017 @default.
- W2562165708 countsByYear W25621657082018 @default.