Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562172851> ?p ?o ?g. }
- W2562172851 abstract "ABSTRACT The Anopheles gambiae complex contains a number of highly anthropophilic mosquito species that have acquired exceptional ability to thrive in complex human habitats. Thus, examining the evolutionary history of this Afrotropical mosquito may yield vital information on the selective processes that occurred during the adaptation to human-dominated environments. We performed reduced representation sequencing on 941 mosquitoes of the Anopheles gambiae complex collected across four ecogeographic zones in Cameroon. We find evidence for genetic and geographic subdivision within An. coluzzii and An. gambiae sensu stricto – the two most significant malaria vectors in the region. Importantly, in both species, rural and urban populations are genetically differentiated. Genome scans reveal pervasive signatures of selection centered on genes involved in xenobiotic resistance. Notably, a selective sweep containing detoxification enzymes is prominent in urban mosquitoes that exploit polluted breeding sites. Overall, our study suggests that recent anthropogenic environmental modifications and widespread use of insecticides are driving population differentiation and local adaptation in vectors with potentially significant consequences for malaria epidemiology." @default.
- W2562172851 created "2017-01-06" @default.
- W2562172851 creator A5057955976 @default.
- W2562172851 creator A5069405482 @default.
- W2562172851 creator A5076264720 @default.
- W2562172851 creator A5079140721 @default.
- W2562172851 date "2016-08-03" @default.
- W2562172851 modified "2023-10-12" @default.
- W2562172851 title "Pollutants and insecticides drive local adaptation in African malaria mosquitoes" @default.
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