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- W2562184414 abstract "Identification of actin-depolymerizing factor homology (ADF-H) domains in the structures of several related proteins led first to the formation of the ADF/cofilin family, which then expanded to the ADF/cofilin superfamily. This superfamily includes the well-studied cofilin-1 (Cfl-1) and about a dozen different human proteins that interact directly or indirectly with the actin cytoskeleton, provide its remodeling, and alter cell motility. According to some data, Cfl-1 is contained in various human malignant cells (HMCs) and is involved in the formation of malignant properties, including invasiveness, metastatic potential, and resistance to chemotherapeutic drugs. The presence of other ADF/cofilin superfamily proteins in HMCs and their involvement in the regulation of cell motility were discovered with the use of various OMICS technologies. In our review, we discuss the results of the study of Cfl-1 and other ADF/cofilin superfamily proteins, which may be of interest for solving different problems of molecular oncology, as well as for the prospects of further investigations of these proteins in HMCs." @default.
- W2562184414 created "2017-01-06" @default.
- W2562184414 creator A5009186299 @default.
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- W2562184414 creator A5022301046 @default.
- W2562184414 creator A5026505703 @default.
- W2562184414 creator A5068867307 @default.
- W2562184414 date "2016-12-22" @default.
- W2562184414 modified "2023-10-04" @default.
- W2562184414 title "Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells" @default.
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