Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562186790> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2562186790 endingPage "2656" @default.
- W2562186790 startingPage "2651" @default.
- W2562186790 abstract "Cysteine oxidation in protamines leads to their oligomerization and contributes to sperm chromatin compaction. Here we identify the Drosophila thioredoxin Deadhead (DHD) as the factor responsible for the reduction of intermolecular disulfide bonds in protamines and their eviction from sperm during fertilization. Protamine chaperone TAP/p32 dissociates DNA-protamine complexes in vitro only when protamine oligomers are first converted to monomers by DHD. dhd-null embryos cannot decondense sperm chromatin and terminate development after the first pronuclear division. Therefore, the thioredoxin DHD plays a critical role in early development to facilitate the switch from protamine-based sperm chromatin structures to the somatic nucleosomal chromatin." @default.
- W2562186790 created "2017-01-06" @default.
- W2562186790 creator A5041179402 @default.
- W2562186790 creator A5067922520 @default.
- W2562186790 date "2016-12-15" @default.
- W2562186790 modified "2023-09-29" @default.
- W2562186790 title "Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin" @default.
- W2562186790 cites W1892819734 @default.
- W2562186790 cites W1974418230 @default.
- W2562186790 cites W1984236721 @default.
- W2562186790 cites W1988876888 @default.
- W2562186790 cites W1991045672 @default.
- W2562186790 cites W1993944463 @default.
- W2562186790 cites W2000834593 @default.
- W2562186790 cites W2006778880 @default.
- W2562186790 cites W2006866503 @default.
- W2562186790 cites W2023829660 @default.
- W2562186790 cites W2025318615 @default.
- W2562186790 cites W2047638806 @default.
- W2562186790 cites W2050406486 @default.
- W2562186790 cites W2055807560 @default.
- W2562186790 cites W2072697652 @default.
- W2562186790 cites W2073746141 @default.
- W2562186790 cites W2079679058 @default.
- W2562186790 cites W2081334998 @default.
- W2562186790 cites W2085076729 @default.
- W2562186790 cites W2087899051 @default.
- W2562186790 cites W2108887652 @default.
- W2562186790 cites W2196284428 @default.
- W2562186790 cites W4245069976 @default.
- W2562186790 cites W4247896860 @default.
- W2562186790 doi "https://doi.org/10.1101/gad.290916.116" @default.
- W2562186790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5238724" @default.
- W2562186790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28031247" @default.
- W2562186790 hasPublicationYear "2016" @default.
- W2562186790 type Work @default.
- W2562186790 sameAs 2562186790 @default.
- W2562186790 citedByCount "27" @default.
- W2562186790 countsByYear W25621867902017 @default.
- W2562186790 countsByYear W25621867902018 @default.
- W2562186790 countsByYear W25621867902019 @default.
- W2562186790 countsByYear W25621867902020 @default.
- W2562186790 countsByYear W25621867902021 @default.
- W2562186790 countsByYear W25621867902022 @default.
- W2562186790 countsByYear W25621867902023 @default.
- W2562186790 crossrefType "journal-article" @default.
- W2562186790 hasAuthorship W2562186790A5041179402 @default.
- W2562186790 hasAuthorship W2562186790A5067922520 @default.
- W2562186790 hasBestOaLocation W25621867901 @default.
- W2562186790 hasConcept C153911025 @default.
- W2562186790 hasConcept C2776151105 @default.
- W2562186790 hasConcept C2777557582 @default.
- W2562186790 hasConcept C2780835560 @default.
- W2562186790 hasConcept C2781087480 @default.
- W2562186790 hasConcept C3623737 @default.
- W2562186790 hasConcept C54355233 @default.
- W2562186790 hasConcept C552990157 @default.
- W2562186790 hasConcept C55493867 @default.
- W2562186790 hasConcept C83640560 @default.
- W2562186790 hasConcept C86803240 @default.
- W2562186790 hasConcept C95444343 @default.
- W2562186790 hasConceptScore W2562186790C153911025 @default.
- W2562186790 hasConceptScore W2562186790C2776151105 @default.
- W2562186790 hasConceptScore W2562186790C2777557582 @default.
- W2562186790 hasConceptScore W2562186790C2780835560 @default.
- W2562186790 hasConceptScore W2562186790C2781087480 @default.
- W2562186790 hasConceptScore W2562186790C3623737 @default.
- W2562186790 hasConceptScore W2562186790C54355233 @default.
- W2562186790 hasConceptScore W2562186790C552990157 @default.
- W2562186790 hasConceptScore W2562186790C55493867 @default.
- W2562186790 hasConceptScore W2562186790C83640560 @default.
- W2562186790 hasConceptScore W2562186790C86803240 @default.
- W2562186790 hasConceptScore W2562186790C95444343 @default.
- W2562186790 hasFunder F4320332161 @default.
- W2562186790 hasIssue "24" @default.
- W2562186790 hasLocation W25621867901 @default.
- W2562186790 hasLocation W25621867902 @default.
- W2562186790 hasLocation W25621867903 @default.
- W2562186790 hasLocation W25621867904 @default.
- W2562186790 hasOpenAccess W2562186790 @default.
- W2562186790 hasPrimaryLocation W25621867901 @default.
- W2562186790 hasRelatedWork W1571465601 @default.
- W2562186790 hasRelatedWork W1575491939 @default.
- W2562186790 hasRelatedWork W2549545655 @default.
- W2562186790 hasRelatedWork W2572979425 @default.
- W2562186790 hasRelatedWork W2790842700 @default.
- W2562186790 hasRelatedWork W2804864469 @default.
- W2562186790 hasRelatedWork W29658203 @default.
- W2562186790 hasRelatedWork W4220683577 @default.
- W2562186790 hasRelatedWork W4309244847 @default.
- W2562186790 hasRelatedWork W841684107 @default.
- W2562186790 hasVolume "30" @default.
- W2562186790 isParatext "false" @default.
- W2562186790 isRetracted "false" @default.
- W2562186790 magId "2562186790" @default.
- W2562186790 workType "article" @default.