FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562199360> ?p ?o ?g. }

• W2562199360 abstract "Boron neutron capture therapy (BNCT) com- bines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. We previously dem- onstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron targeting to tumor cells. Seeking to maximize the potential of BNCT for the treatment for head and neck cancer, the aim of the present study was to perform boron biodistribution studies in the oral cancer model employing two different liposome formulations that were previously tested for a different pathology, i.e., in experimental mammary carcinoma in BALB/c mice: (1) MAC: liposomes incorporating K(nido-7-CH3(CH2)15-7,8-C2B9 H11) in the bilayer membrane and encapsulating a hypertonic buffer, administered intravenously at 6 mg B per kg body weight, and (2) MAC-TAC: liposomes incorporating K(nido-7-CH3(CH2)15-7,8-C2B9H11) in the bilayer mem- brane and encapsulating a concentrated aqueous solution of the hydrophilic species Na3 (ae-B20H17NH3), administered intravenously at 18 mg B per kg body weight. Samples of tumor, precancerous and normal pouch tissue, spleen, liver, kidney, and blood were taken at different times post- administration and processed to measure boron content by inductively coupled plasma mass spectrometry. No osten- sible clinical toxic effects were observed with the selected formulations. Both MAC and MAC-TAC delivered boron selectively to tumor tissue. Absolute tumor values for MAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to 43.9 ± 17.6 ppm at 54 h with very favorable ratios of tumor boron relative to precancerous and normal tissue, making these protocols particularly worthy of radiobiological assessment. Boron concentration values obtained would result in therapeutic BNCT doses in tumor without exceed- ing radiotolerance in precancerous/normal tissue at the thermal neutron facility at RA-3." @default.
• W2562199360 created "2017-01-06" @default.
• W2562199360 creator A5007164113 @default.
• W2562199360 creator A5012553025 @default.
• W2562199360 creator A5012969071 @default.
• W2562199360 creator A5031748120 @default.
• W2562199360 creator A5038424554 @default.
• W2562199360 creator A5043997856 @default.
• W2562199360 creator A5050378928 @default.
• W2562199360 creator A5058971947 @default.
• W2562199360 creator A5060645588 @default.
• W2562199360 creator A5074310043 @default.
• W2562199360 creator A5074414779 @default.
• W2562199360 date "2012-01-01" @default.
• W2562199360 modified "2023-09-27" @default.
• W2562199360 title "Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential Elisa M. HeberPeter J. KuefferMark W. Lee Jr. • M. Frederick Hawthorne • Marcela A. GarabalinoAna J. MolinariDavid W. NiggWilliam Bauer • Andrea Monti HughesEmiliano C. C. PozziVeronica A. TrivillinAmanda E. Schwint" @default.
• W2562199360 cites W1573363574 @default.
• W2562199360 cites W1646183870 @default.
• W2562199360 cites W1796385612 @default.
• W2562199360 cites W1871308790 @default.
• W2562199360 cites W1970216633 @default.
• W2562199360 cites W1980422006 @default.
• W2562199360 cites W1987744910 @default.
• W2562199360 cites W1990983926 @default.
• W2562199360 cites W1992076192 @default.
• W2562199360 cites W2001672323 @default.
• W2562199360 cites W2003738198 @default.
• W2562199360 cites W2006202974 @default.
• W2562199360 cites W2009401675 @default.
• W2562199360 cites W2010897296 @default.
• W2562199360 cites W2012200796 @default.
• W2562199360 cites W2013053295 @default.
• W2562199360 cites W2013180172 @default.
• W2562199360 cites W2019474752 @default.
• W2562199360 cites W2019845574 @default.
• W2562199360 cites W2020057753 @default.
• W2562199360 cites W2022948143 @default.
• W2562199360 cites W2024660611 @default.
• W2562199360 cites W2025632480 @default.
• W2562199360 cites W2025853365 @default.
• W2562199360 cites W2037185264 @default.
• W2562199360 cites W2037803591 @default.
• W2562199360 cites W2039332880 @default.
• W2562199360 cites W203998073 @default.
• W2562199360 cites W2046159770 @default.
• W2562199360 cites W2046333152 @default.
• W2562199360 cites W2052244510 @default.
• W2562199360 cites W2054200229 @default.
• W2562199360 cites W2055341486 @default.
• W2562199360 cites W2055943955 @default.
• W2562199360 cites W2057240258 @default.
• W2562199360 cites W2063349980 @default.
• W2562199360 cites W2066854751 @default.
• W2562199360 cites W2067043175 @default.
• W2562199360 cites W2079784437 @default.
• W2562199360 cites W2081635119 @default.
• W2562199360 cites W2087056884 @default.
• W2562199360 cites W2090716553 @default.
• W2562199360 cites W2093760550 @default.
• W2562199360 cites W2097807191 @default.
• W2562199360 cites W2111026462 @default.
• W2562199360 cites W2119046971 @default.
• W2562199360 cites W2120447583 @default.
• W2562199360 cites W2123247779 @default.
• W2562199360 cites W2125812742 @default.
• W2562199360 cites W2137277148 @default.
• W2562199360 cites W2139746972 @default.
• W2562199360 cites W2145030327 @default.
• W2562199360 cites W2167534214 @default.
• W2562199360 cites W2220362953 @default.
• W2562199360 cites W2468470429 @default.
• W2562199360 cites W591339985 @default.
• W2562199360 hasPublicationYear "2012" @default.
• W2562199360 type Work @default.
• W2562199360 sameAs 2562199360 @default.
• W2562199360 citedByCount "0" @default.
• W2562199360 crossrefType "journal-article" @default.
• W2562199360 hasAuthorship W2562199360A5007164113 @default.
• W2562199360 hasAuthorship W2562199360A5012553025 @default.
• W2562199360 hasAuthorship W2562199360A5012969071 @default.
• W2562199360 hasAuthorship W2562199360A5031748120 @default.
• W2562199360 hasAuthorship W2562199360A5038424554 @default.
• W2562199360 hasAuthorship W2562199360A5043997856 @default.
• W2562199360 hasAuthorship W2562199360A5050378928 @default.
• W2562199360 hasAuthorship W2562199360A5058971947 @default.
• W2562199360 hasAuthorship W2562199360A5060645588 @default.
• W2562199360 hasAuthorship W2562199360A5074310043 @default.
• W2562199360 hasAuthorship W2562199360A5074414779 @default.
• W2562199360 hasConcept C112705442 @default.
• W2562199360 hasConcept C121608353 @default.
• W2562199360 hasConcept C126322002 @default.
• W2562199360 hasConcept C142724271 @default.
• W2562199360 hasConcept C150903083 @default.
• W2562199360 hasConcept C177322064 @default.
• W2562199360 hasConcept C178790620 @default.
• W2562199360 hasConcept C185154212 @default.
• W2562199360 hasConcept C185592680 @default.
• W2562199360 hasConcept C202751555 @default.
• W2562199360 hasConcept C207001950 @default.
• W2562199360 hasConcept C2777807558 @default.

• next