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- W2562222733 abstract "Significance The extracellular production of hydrogen peroxide (H 2 O 2 ) by membrane or secreted oxidases has been linked to epithelial wound repair, defense against infection, and inflammation. Here, we elucidate the pathway that explains how extracellular H 2 O 2 transduces a signal into the cell to induce these critical cell functions. Our study shows the central component of this pathway in the mammalian colon is the H 2 O 2 -conducting aquaglyceroporin AQP3 and implicates this channel in innate immune responses at mucosal surfaces." @default.
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- W2562222733 date "2017-01-03" @default.
- W2562222733 modified "2023-10-02" @default.
- W2562222733 title "Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia" @default.
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- W2562222733 doi "https://doi.org/10.1073/pnas.1612921114" @default.
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