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• W2562241370 abstract "Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into the mechanisms leading to motor neuron death. Moreover, mutations in two RNA binding proteins, TAR DNA binding protein 43 and fused in sarcoma, have raised the intriguing possibility that perturbations of RNA metabolism, including that of the small endogenous RNA molecules that repress target genes at the posttranscriptional level, that is, microRNAs, may contribute to disease pathogenesis. At present, the mechanisms by which microglia actively participate to both toxic and neuroprotective actions in ALS constitute an important matter of research. Among the pathways involved in ALS-altered microglia responses, in previous works we have uncovered the hyperactivation of P2X7 receptor by extracellular ATP and the overexpression of miR-125b, both leading to uncontrolled toxic M1 reactions. In order to shed further light on the complexity of these processes, in this short review we will describe the M1/M2 functional imprinting of primary microglia and a role played by P2X7 and miR-125b in ALS microglia activation." @default.
• W2562241370 created "2017-01-06" @default.
• W2562241370 creator A5004456926 @default.
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• W2562241370 date "2016-01-01" @default.
• W2562241370 modified "2023-10-10" @default.
• W2562241370 title "M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b" @default.
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• W2562241370 cites W1581535372 @default.
• W2562241370 cites W1593579053 @default.
• W2562241370 cites W1596801838 @default.
• W2562241370 cites W1817666133 @default.
• W2562241370 cites W1823267164 @default.
• W2562241370 cites W1830916283 @default.
• W2562241370 cites W1955522487 @default.
• W2562241370 cites W1964229968 @default.
• W2562241370 cites W1987015752 @default.
• W2562241370 cites W1987138690 @default.
• W2562241370 cites W1988491332 @default.
• W2562241370 cites W1992065280 @default.
• W2562241370 cites W1992353205 @default.
• W2562241370 cites W2000104675 @default.
• W2562241370 cites W2001428704 @default.
• W2562241370 cites W2003147175 @default.
• W2562241370 cites W2003674452 @default.
• W2562241370 cites W2007226629 @default.
• W2562241370 cites W2009030515 @default.
• W2562241370 cites W2013471060 @default.
• W2562241370 cites W2015738975 @default.
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• W2562241370 cites W2030638552 @default.
• W2562241370 cites W2030893485 @default.
• W2562241370 cites W2032669538 @default.
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• W2562241370 cites W2033810895 @default.
• W2562241370 cites W2040773899 @default.
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• W2562241370 cites W2066828509 @default.
• W2562241370 cites W2082405845 @default.
• W2562241370 cites W2084231086 @default.
• W2562241370 cites W2088859543 @default.
• W2562241370 cites W2093457368 @default.
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• W2562241370 cites W2101321540 @default.
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• W2562241370 cites W2106756035 @default.
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• W2562241370 cites W2161838835 @default.
• W2562241370 cites W2163022074 @default.
• W2562241370 cites W2167912995 @default.
• W2562241370 cites W2170959966 @default.
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• W2562241370 doi "https://doi.org/10.1155/2016/2989548" @default.
• W2562241370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5206439" @default.
• W2562241370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28090150" @default.
• W2562241370 hasPublicationYear "2016" @default.
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