Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562243521> ?p ?o ?g. }
- W2562243521 endingPage "795" @default.
- W2562243521 startingPage "785" @default.
- W2562243521 abstract "B-cell maturation antigen is expressed on plasma cells. In this study, we have identified serum B-cell maturation antigen as a novel biomarker that can monitor and predict outcomes for multiple myeloma patients. Compared to healthy donors, patients with multiple myeloma showed elevated serum B-cell maturation antigen levels (P<0.0001). Serum B-cell maturation antigen levels correlated with the proportion of plasma cells in bone marrow biopsies (Spearman's rho = 0.710; P<0.001), clinical status (complete response vs partial response, P=0.0374; complete response vs progressive disease, P<0.0001), and tracked with changes in M-protein levels. Among patients with non-secretory disease, serum B-cell maturation antigen levels correlated with bone marrow plasma cell levels and findings from positron emission tomography scans. Kaplan-Meier analysis demonstrated that serum B-cell maturation antigen levels above the median levels were predictive of a shorter progression-free survival (P=0.0006) and overall survival (P=0.0108) among multiple myeloma patients (n=243). Specifically, patients with serum B-cell maturation antigen levels above the median level at the time of starting front-line (P=0.0043) or a new salvage therapy (P=0.0044) were found to have shorter progression-free survival. Importantly, serum B-cell maturation antigen levels did not show any dependence on renal function and maintained independent significance when tested against other known prognostic markers for multiple myeloma such as age, serum β2 microglobulin, hemoglobin, and bone disease. These data identify serum B-cell maturation antigen as a new biomarker to manage multiple myeloma patients." @default.
- W2562243521 created "2017-01-06" @default.
- W2562243521 creator A5002726139 @default.
- W2562243521 creator A5005405176 @default.
- W2562243521 creator A5018622970 @default.
- W2562243521 creator A5019989988 @default.
- W2562243521 creator A5021554856 @default.
- W2562243521 creator A5038431825 @default.
- W2562243521 creator A5040835019 @default.
- W2562243521 creator A5042782142 @default.
- W2562243521 creator A5044039905 @default.
- W2562243521 creator A5061288330 @default.
- W2562243521 creator A5068437316 @default.
- W2562243521 creator A5070663510 @default.
- W2562243521 creator A5076184600 @default.
- W2562243521 creator A5084655684 @default.
- W2562243521 creator A5090300095 @default.
- W2562243521 date "2016-12-29" @default.
- W2562243521 modified "2023-10-15" @default.
- W2562243521 title "Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients" @default.
- W2562243521 cites W105015979 @default.
- W2562243521 cites W1255129347 @default.
- W2562243521 cites W1507988772 @default.
- W2562243521 cites W1533841403 @default.
- W2562243521 cites W1534557867 @default.
- W2562243521 cites W1747565189 @default.
- W2562243521 cites W185427134 @default.
- W2562243521 cites W187373797 @default.
- W2562243521 cites W1903203537 @default.
- W2562243521 cites W1912299294 @default.
- W2562243521 cites W1969568409 @default.
- W2562243521 cites W1970326499 @default.
- W2562243521 cites W1982877913 @default.
- W2562243521 cites W1991978462 @default.
- W2562243521 cites W2002048624 @default.
- W2562243521 cites W2004275290 @default.
- W2562243521 cites W2013296669 @default.
- W2562243521 cites W2021510332 @default.
- W2562243521 cites W2042728261 @default.
- W2562243521 cites W2043396394 @default.
- W2562243521 cites W2044436186 @default.
- W2562243521 cites W2049209813 @default.
- W2562243521 cites W2063208192 @default.
- W2562243521 cites W2066800926 @default.
- W2562243521 cites W2072114878 @default.
- W2562243521 cites W2077015738 @default.
- W2562243521 cites W2100799644 @default.
- W2562243521 cites W2102694800 @default.
- W2562243521 cites W2119462367 @default.
- W2562243521 cites W2120474651 @default.
- W2562243521 cites W2125749190 @default.
- W2562243521 cites W2126120941 @default.
- W2562243521 cites W2147495729 @default.
- W2562243521 cites W2150518976 @default.
- W2562243521 cites W2151034091 @default.
- W2562243521 cites W2158415042 @default.
- W2562243521 cites W2160088903 @default.
- W2562243521 cites W2162224041 @default.
- W2562243521 cites W2168073366 @default.
- W2562243521 cites W2182681254 @default.
- W2562243521 cites W2295721179 @default.
- W2562243521 cites W2304737870 @default.
- W2562243521 cites W2335662053 @default.
- W2562243521 cites W2345369200 @default.
- W2562243521 cites W2417864726 @default.
- W2562243521 cites W2559100492 @default.
- W2562243521 cites W30501128 @default.
- W2562243521 doi "https://doi.org/10.3324/haematol.2016.150896" @default.
- W2562243521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5395119" @default.
- W2562243521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28034989" @default.
- W2562243521 hasPublicationYear "2016" @default.
- W2562243521 type Work @default.
- W2562243521 sameAs 2562243521 @default.
- W2562243521 citedByCount "108" @default.
- W2562243521 countsByYear W25622435212017 @default.
- W2562243521 countsByYear W25622435212018 @default.
- W2562243521 countsByYear W25622435212019 @default.
- W2562243521 countsByYear W25622435212020 @default.
- W2562243521 countsByYear W25622435212021 @default.
- W2562243521 countsByYear W25622435212022 @default.
- W2562243521 countsByYear W25622435212023 @default.
- W2562243521 crossrefType "journal-article" @default.
- W2562243521 hasAuthorship W2562243521A5002726139 @default.
- W2562243521 hasAuthorship W2562243521A5005405176 @default.
- W2562243521 hasAuthorship W2562243521A5018622970 @default.
- W2562243521 hasAuthorship W2562243521A5019989988 @default.
- W2562243521 hasAuthorship W2562243521A5021554856 @default.
- W2562243521 hasAuthorship W2562243521A5038431825 @default.
- W2562243521 hasAuthorship W2562243521A5040835019 @default.
- W2562243521 hasAuthorship W2562243521A5042782142 @default.
- W2562243521 hasAuthorship W2562243521A5044039905 @default.
- W2562243521 hasAuthorship W2562243521A5061288330 @default.
- W2562243521 hasAuthorship W2562243521A5068437316 @default.
- W2562243521 hasAuthorship W2562243521A5070663510 @default.
- W2562243521 hasAuthorship W2562243521A5076184600 @default.
- W2562243521 hasAuthorship W2562243521A5084655684 @default.
- W2562243521 hasAuthorship W2562243521A5090300095 @default.
- W2562243521 hasBestOaLocation W25622435211 @default.