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• W2562334089 abstract "Background Malignant mesothelioma is an aggressive tumor of serosal surfaces that is closely associated with asbestos exposure which induces oxidative stress. Heme oxygenase (HO)-1, a rate-limiting enzyme of heme degradation, plays a protective role against oxidative stress. The HO-1 gene promoter carries (GT)n repeats whose number is inversely related to transcriptional activity of the HO-1 gene. Methods To investigate the relationship between the length polymorphism of (GT)n repeats and mesothelioma susceptibility, we analyzed the HO-1 promoter in 44 asbestos-exposed subjects without mesothelioma and 78 asbestos-exposed subjects with mesothelioma using PCRbased genotyping. Results The number of repeats ranged from 16 to 38, with two peaks at 23 and 30 repeats. Polymorphisms of (GT)n repeats were grouped into two classes of alleles, short (S) (24) and long (L) (C24), and three genotypes: L/L, L/S, and S/S. The proportions of allele frequencies in class L as well as genotypic frequencies of L allele carriers (L/L and L/S) were significantly higher in the asbestosexposed subjects with mesothelioma than in those without mesothelioma. Conclusion The findings of this study suggest that long (GT)n repeats in the HO-1 gene promoter are associated with a higher risk of malignant mesothelioma in the Japanese population." @default.
• W2562334089 created "2017-01-06" @default.
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• W2562334089 date "2012-01-01" @default.
• W2562334089 modified "2023-09-27" @default.
• W2562334089 title "Heme Oxygenase-1 Promoter Polymorphism is Associated with Risk of Malignant Mesothelioma Aki MurakamiYoshihiro FujimoriYoshie YoshikawaShusai Yamada • Kunihiro TamuraNoriko HirayamaTakayuki TeradaKozo Kuribayashi • Chiharu TabataKazuya FukuokaTomoko TamaokiTakashi Nakano" @default.
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