Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562372724> ?p ?o ?g. }
- W2562372724 endingPage "168" @default.
- W2562372724 startingPage "160" @default.
- W2562372724 abstract "Hepatic sinusoidal obstruction syndrome (SOS) is a rare liver disease with considerable mortality. This study is designed to observe the protection of quercetin and baicalein against monocrotaline (MCT)-induced SOS in rats and its engaged mechanism. Rats were pre-administrated with MCT (90mg/kg) to induce SOS, and 6, 30h later were orally given with quercetin and baicalein (40mg/kg) twice. Results of detecting rats with liver ascites, measuring serum transaminases, total bilirubin (TBil) and bile acids (TBA), analyzing blood cells, liver histological evaluation and scanning electron microscope observation all demonstrated the detoxification of quercetin and baicalein against MCT-induced SOS in rats. Quercetin and baicalein reduced the increased metalloproteinase-9 (MMP-9) expression, liver myeloperoxidase (MPO) activity, toll-like receptor (TLR)-2,3,6,9 expression and nuclear factor κB (NFκB) transcriptional activation induced by MCT. Quercetin and baicalein reduced MCT-induced nuclear translocation of early growth response1 (Egr1) and increased expression of Serpine1 and tissue factor (TF). Quercetin and baicalein reduced MCT-induced increased liver malondialdehyde (MDA) amount and enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Quercetin and baicalein also abrogated MCT-induced activation of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol 3-kinase (PI3K) signaling cascades. In conclusion, this study demonstrated the protection of quercetin and baicalein against MCT-induced SOS in rats, indicating the potential application of them for the treatment of SOS in clinic. Transcriptional factor NFκB, Egr1 and Nrf2-regulated inflammation, coagulation-fibrinolysis and antioxidant, and PI3K and MAPKs signaling cascades are all involved such protection." @default.
- W2562372724 created "2017-01-06" @default.
- W2562372724 creator A5011479283 @default.
- W2562372724 creator A5020285133 @default.
- W2562372724 creator A5021283106 @default.
- W2562372724 creator A5022096000 @default.
- W2562372724 creator A5027145131 @default.
- W2562372724 creator A5040256881 @default.
- W2562372724 creator A5090619564 @default.
- W2562372724 date "2017-01-01" @default.
- W2562372724 modified "2023-10-06" @default.
- W2562372724 title "Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats" @default.
- W2562372724 cites W1192899902 @default.
- W2562372724 cites W1607074086 @default.
- W2562372724 cites W1754648675 @default.
- W2562372724 cites W1965298744 @default.
- W2562372724 cites W1967758438 @default.
- W2562372724 cites W1967996072 @default.
- W2562372724 cites W1968157613 @default.
- W2562372724 cites W1973449234 @default.
- W2562372724 cites W1973451690 @default.
- W2562372724 cites W1978472019 @default.
- W2562372724 cites W1980739328 @default.
- W2562372724 cites W1982641003 @default.
- W2562372724 cites W1987810847 @default.
- W2562372724 cites W1991218671 @default.
- W2562372724 cites W1993783426 @default.
- W2562372724 cites W2006201383 @default.
- W2562372724 cites W2010646889 @default.
- W2562372724 cites W2012054541 @default.
- W2562372724 cites W2030954875 @default.
- W2562372724 cites W2039156870 @default.
- W2562372724 cites W2042360445 @default.
- W2562372724 cites W2045176214 @default.
- W2562372724 cites W2048398316 @default.
- W2562372724 cites W2048708819 @default.
- W2562372724 cites W2059149560 @default.
- W2562372724 cites W2061903251 @default.
- W2562372724 cites W2075766764 @default.
- W2562372724 cites W2080813308 @default.
- W2562372724 cites W2080897456 @default.
- W2562372724 cites W2090199353 @default.
- W2562372724 cites W2098180581 @default.
- W2562372724 cites W2101363646 @default.
- W2562372724 cites W2115436938 @default.
- W2562372724 cites W2121868928 @default.
- W2562372724 cites W2122712927 @default.
- W2562372724 cites W2129447035 @default.
- W2562372724 cites W2130796934 @default.
- W2562372724 cites W2143007780 @default.
- W2562372724 cites W2143804584 @default.
- W2562372724 cites W2144917307 @default.
- W2562372724 cites W2144919352 @default.
- W2562372724 cites W2151892297 @default.
- W2562372724 cites W2316688214 @default.
- W2562372724 cites W2329045407 @default.
- W2562372724 cites W4296391086 @default.
- W2562372724 cites W869287652 @default.
- W2562372724 cites W978523268 @default.
- W2562372724 doi "https://doi.org/10.1016/j.ejphar.2016.12.015" @default.
- W2562372724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27979702" @default.
- W2562372724 hasPublicationYear "2017" @default.
- W2562372724 type Work @default.
- W2562372724 sameAs 2562372724 @default.
- W2562372724 citedByCount "30" @default.
- W2562372724 countsByYear W25623727242017 @default.
- W2562372724 countsByYear W25623727242018 @default.
- W2562372724 countsByYear W25623727242019 @default.
- W2562372724 countsByYear W25623727242020 @default.
- W2562372724 countsByYear W25623727242021 @default.
- W2562372724 countsByYear W25623727242022 @default.
- W2562372724 crossrefType "journal-article" @default.
- W2562372724 hasAuthorship W2562372724A5011479283 @default.
- W2562372724 hasAuthorship W2562372724A5020285133 @default.
- W2562372724 hasAuthorship W2562372724A5021283106 @default.
- W2562372724 hasAuthorship W2562372724A5022096000 @default.
- W2562372724 hasAuthorship W2562372724A5027145131 @default.
- W2562372724 hasAuthorship W2562372724A5040256881 @default.
- W2562372724 hasAuthorship W2562372724A5090619564 @default.
- W2562372724 hasConcept C126322002 @default.
- W2562372724 hasConcept C134018914 @default.
- W2562372724 hasConcept C185592680 @default.
- W2562372724 hasConcept C2778004101 @default.
- W2562372724 hasConcept C2781263971 @default.
- W2562372724 hasConcept C2781466915 @default.
- W2562372724 hasConcept C55493867 @default.
- W2562372724 hasConcept C71924100 @default.
- W2562372724 hasConcept C98274493 @default.
- W2562372724 hasConceptScore W2562372724C126322002 @default.
- W2562372724 hasConceptScore W2562372724C134018914 @default.
- W2562372724 hasConceptScore W2562372724C185592680 @default.
- W2562372724 hasConceptScore W2562372724C2778004101 @default.
- W2562372724 hasConceptScore W2562372724C2781263971 @default.
- W2562372724 hasConceptScore W2562372724C2781466915 @default.
- W2562372724 hasConceptScore W2562372724C55493867 @default.
- W2562372724 hasConceptScore W2562372724C71924100 @default.
- W2562372724 hasConceptScore W2562372724C98274493 @default.
- W2562372724 hasFunder F4320321001 @default.