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- W2562418371 abstract "Abstract Signaling pathways represent parts of the global biological network which connects them into a seamless whole through complex direct and indirect (hidden) crosstalk whose structure can change during development or in pathological conditions. We suggest a novel methodology, called Googlomics, for the structural analysis of directed biological networks using spectral analysis of their Google matrices, using parallels with quantum scattering theory, developed for nuclear and mesoscopic physics and quantum chaos. We introduce the reduced Google matrix method for the regulatory biological networks and demonstrate how its computation allows inferring hidden causal relations between the members of a signaling pathway or a functionally related group of genes. We investigate how the structure of hidden causal relations can be reprogrammed as the result of changes in the transcriptional network layer during cancerogenesis. The suggested Googlomics approach rigorously characterizes complex systemic changes in the wiring of large causal biological networks." @default.
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- W2562418371 date "2016-12-22" @default.
- W2562418371 modified "2023-10-04" @default.
- W2562418371 title "Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks" @default.
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- W2562418371 doi "https://doi.org/10.1101/096362" @default.
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