FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562473764> ?p ?o ?g. }

• W2562473764 endingPage "1392" @default.
• W2562473764 startingPage "1386" @default.
• W2562473764 abstract "The present study aimed to evaluate the correlation between the expression of microRNA-146a (miR-146a) and its target gene, LIN52, in advanced gastric cancer, and determine their potential effects on chemotherapeutic sensitivity and prognosis. Total RNA was extracted from 93 tissue samples of advanced gastric cancer and corresponding adjacent non‑tumor tissues to quantify the relative expression levels of miR‑146a using reverse transcription‑quantitative polymerase chain reaction analysis. The expression of LIN52 was detected in tumors and normal tissues using immunohistochemical analysis. Correlation analysis was performed to assess the correlation between the expression of miR‑146a and LIN52 and clinicopathological parameters of gastric cancer, including clinical diagnostic specificity, clinical tumor‑necrosis‑metastasis staging, lymph node metastasis, differentiation grade, chemotherapeutic sensitivity and prognosis. The expression of miR‑146a in advanced gastric cancer tissues was lower, compared with that in the adjacent non‑tumor tissues, and was negatively correlated with lymph node metastasis (P<0.05). Gastric cancer tissues with a low expression level of miR146a exhibited an increased expression level of LIN52 (P<0.05). Receiver operating characteristic curve regression analysis showed that miR‑146a had 98% sensitivity in distinguishing gastric cancer tissues and adjacent non‑tumor tissues. A high expression of miR‑146a in gastric cancer was associated with improved treatment efficacy in patients. The chemotherapeutic sensitivity of patients with tumors expressing high levels of miR‑146a was significantly higher, compared with that of patients with tumors expressing low levels of miR‑146a (P<0.05). The expression of miR‑146a was low in advanced gastric cancer tissues. As a tumor suppressor gene in advanced gastric cancer, miR‑146a had a significant negative correlation with LIN52. High expression levels of miR‑146a in advanced gastric cancer tissue may be associated with improved treatment efficacy of chemotherapy, suggesting that miR‑146a may be a molecular marker for the diagnosis, prediction of treatment efficacy and prognosis of advanced gastric cancer." @default.
• W2562473764 created "2017-01-06" @default.
• W2562473764 creator A5019899920 @default.
• W2562473764 creator A5037330078 @default.
• W2562473764 creator A5044206518 @default.
• W2562473764 creator A5047004828 @default.
• W2562473764 creator A5074326183 @default.
• W2562473764 creator A5091743478 @default.
• W2562473764 date "2016-12-27" @default.
• W2562473764 modified "2023-09-27" @default.
• W2562473764 title "MicroRNA-146a affects the chemotherapeutic sensitivity and prognosis of advanced gastric cancer through the regulation of LIN52" @default.
• W2562473764 cites W1588142016 @default.
• W2562473764 cites W1633718512 @default.
• W2562473764 cites W1706170269 @default.
• W2562473764 cites W1768367957 @default.
• W2562473764 cites W1971995493 @default.
• W2562473764 cites W1973386532 @default.
• W2562473764 cites W1978086123 @default.
• W2562473764 cites W1979855433 @default.
• W2562473764 cites W1986463878 @default.
• W2562473764 cites W1995134618 @default.
• W2562473764 cites W1996415723 @default.
• W2562473764 cites W1998153888 @default.
• W2562473764 cites W2000006839 @default.
• W2562473764 cites W2016896948 @default.
• W2562473764 cites W2018928655 @default.
• W2562473764 cites W2041739576 @default.
• W2562473764 cites W2055471397 @default.
• W2562473764 cites W2059073003 @default.
• W2562473764 cites W2066245403 @default.
• W2562473764 cites W2074845792 @default.
• W2562473764 cites W2074897936 @default.
• W2562473764 cites W2094895072 @default.
• W2562473764 cites W2115610111 @default.
• W2562473764 cites W2121659696 @default.
• W2562473764 cites W2126108346 @default.
• W2562473764 cites W2134051389 @default.
• W2562473764 cites W2135382291 @default.
• W2562473764 cites W2135594199 @default.
• W2562473764 cites W2135810600 @default.
• W2562473764 cites W2149966907 @default.
• W2562473764 cites W2152053639 @default.
• W2562473764 cites W2152349800 @default.
• W2562473764 cites W2165007898 @default.
• W2562473764 cites W2167619577 @default.
• W2562473764 cites W2171697766 @default.
• W2562473764 cites W2508156416 @default.
• W2562473764 cites W2522605738 @default.
• W2562473764 cites W2547009394 @default.
• W2562473764 doi "https://doi.org/10.3892/ol.2016.5536" @default.
• W2562473764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5403335" @default.
• W2562473764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28454266" @default.
• W2562473764 hasPublicationYear "2016" @default.
• W2562473764 type Work @default.
• W2562473764 sameAs 2562473764 @default.
• W2562473764 citedByCount "6" @default.
• W2562473764 countsByYear W25624737642017 @default.
• W2562473764 countsByYear W25624737642019 @default.
• W2562473764 countsByYear W25624737642021 @default.
• W2562473764 countsByYear W25624737642022 @default.
• W2562473764 countsByYear W25624737642023 @default.
• W2562473764 crossrefType "journal-article" @default.
• W2562473764 hasAuthorship W2562473764A5019899920 @default.
• W2562473764 hasAuthorship W2562473764A5037330078 @default.
• W2562473764 hasAuthorship W2562473764A5044206518 @default.
• W2562473764 hasAuthorship W2562473764A5047004828 @default.
• W2562473764 hasAuthorship W2562473764A5074326183 @default.
• W2562473764 hasAuthorship W2562473764A5091743478 @default.
• W2562473764 hasBestOaLocation W25624737641 @default.
• W2562473764 hasConcept C104317684 @default.
• W2562473764 hasConcept C121608353 @default.
• W2562473764 hasConcept C126322002 @default.
• W2562473764 hasConcept C142724271 @default.
• W2562473764 hasConcept C143998085 @default.
• W2562473764 hasConcept C145059251 @default.
• W2562473764 hasConcept C204232928 @default.
• W2562473764 hasConcept C2779013556 @default.
• W2562473764 hasConcept C2780849966 @default.
• W2562473764 hasConcept C2781018059 @default.
• W2562473764 hasConcept C29537977 @default.
• W2562473764 hasConcept C502942594 @default.
• W2562473764 hasConcept C55493867 @default.
• W2562473764 hasConcept C67082663 @default.
• W2562473764 hasConcept C71924100 @default.
• W2562473764 hasConcept C86803240 @default.
• W2562473764 hasConceptScore W2562473764C104317684 @default.
• W2562473764 hasConceptScore W2562473764C121608353 @default.
• W2562473764 hasConceptScore W2562473764C126322002 @default.
• W2562473764 hasConceptScore W2562473764C142724271 @default.
• W2562473764 hasConceptScore W2562473764C143998085 @default.
• W2562473764 hasConceptScore W2562473764C145059251 @default.
• W2562473764 hasConceptScore W2562473764C204232928 @default.
• W2562473764 hasConceptScore W2562473764C2779013556 @default.
• W2562473764 hasConceptScore W2562473764C2780849966 @default.
• W2562473764 hasConceptScore W2562473764C2781018059 @default.
• W2562473764 hasConceptScore W2562473764C29537977 @default.
• W2562473764 hasConceptScore W2562473764C502942594 @default.
• W2562473764 hasConceptScore W2562473764C55493867 @default.

• next